Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Herrera, M, Sparks, MA, and Coffman, TM. "Lack of specificity for AT1 angiotensin receptor antibodies in Western blot analysis." Experimental Biology Meeting. San Diego, CA. April 21, 2012 - April 25, 2012.: FEDERATION AMER SOC EXP BIOL, April 1, 2012.

Scholars@Duke

Herrera, M, and Coffman, TM. "The kidney and hypertension: novel insights from transgenic models." Curr Opin Nephrol Hypertens 21, no. 2 (March 2012): 171-178. (Review)

PMID
22274801
Full Text

Cyphert, JM, Allen, IC, Church, RJ, Latour, AM, Snouwaert, JN, Coffman, TM, and Koller, BH. "Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse." American Journal of Physiology. Lung Cellular and Molecular Physiology 302, no. 1 (January 2012): L140-L151.

PMID
21984570
Full Text

Verlander, JW, Hong, S, Pech, V, Bailey, JL, Agazatian, D, Matthews, SW, Coffman, TM, Le, T, Inagami, T, Whitehill, FM, Weiner, ID, Farley, DB, Kim, YH, and Wall, SM. "Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin." American Journal of Physiology Renal Physiology 301, no. 6 (December 2011): F1314-F1325.

PMID
21921024
Full Text

Stegbauer, J, Gurley, SB, Sparks, MA, Woznowski, M, Kohan, DE, Yan, M, Lehrich, RW, and Coffman, TM. "AT1 receptors in the collecting duct directly modulate the concentration of urine." J Am Soc Nephrol 22, no. 12 (December 2011): 2237-2246.

PMID
22052052
Full Text

Facemire, CS, Nguyen, M, Jania, L, Beierwaltes, WH, Kim, H-S, Koller, BH, and Coffman, TM. "A major role for the EP4 receptor in regulation of renin." American Journal of Physiology Renal Physiology 301, no. 5 (November 2011): F1035-F1041.

PMID
21835766
Full Text

Sparks, MA, Stegbauer, J, Gurley, SB, and Coffman, TM. "Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Contribute to Blood Pressure Control, Salt Sensitivity and Hypertension." November 2011.

Scholars@Duke

Herrera, M, Stegbauer, J, Gurley, SB, and Coffman, TM. "AT1 Receptor Activation Stimulates COX2 Expression in Mouse Collecting Duct Epithelium." November 2011.

Scholars@Duke

Gembardt, F, van Esch, JH, Coffman, TM, Schultheiss, H-P, Danser, AHJ, and Walther, T. "Hemodynamic Effects of Angiotensin-(1-7) Do Not Depend On AT1 Or AT2." Scientific Sessions of High Blood Pressure Research. Orlando, FL. September 20, 2011 - September 24, 2011.: LIPPINCOTT WILLIAMS & WILKINS, November 1, 2011.

Scholars@Duke

Young, CN, Butler, SD, Li, A, Parsons, KK, Coffman, TM, Mark, AL, and Davisson, RL. "Angiotensin Type 1a Receptors (AT(1a)) in the Subfornical Organ Contribute to the Weight-Reducing Effects of Leptin." High Blood Pressure Research Scientific Sessions. Orlando, FL. September 20, 2011 - September 24, 2011.: LIPPINCOTT WILLIAMS & WILKINS, November 1, 2011.

Scholars@Duke

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