Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Facemire, CS, Griffiths, R, Audoly, LP, Koller, BH, and Coffman, TM. "The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background." Hypertension 55, no. 2 (February 2010): 531-538.

PMID
20065147
Full Text

Sparks, MA, and Coffman, TM. "The EP4 receptor for prostaglandin E2in glomerular disease: A good receptor turned bad?." Journal of the American Society of Nephrology 21, no. 10 (2010): 1597-1599.

PMID
20829404
Full Text

Esch, JHMV, Gembardt, F, Sterner-Kock, A, Heringer-Walther, S, Le, TH, Laßner, D, Stijnen, T, Coffman, TM, Schultheiss, H-P, Danser, AHJ, and Walther, T. "Cardiac phenotype and angiotensin II levels in AT1a, AT 1b, and AT2 receptor single, double, and triple knockouts." Cardiovascular Research 86, no. 3 (2010): 401-409.

PMID
20071356
Full Text

Madsen, K, Marcussen, N, Pedersen, M, Kjærsgaard, G, Facemire, C, Coffman, TM, and Jensen, BL. "Angiotensin II promotes development of the renal microcirculation through AT1 receptors." Journal of the American Society of Nephrology 21, no. 3 (2010): 448-459.

PMID
20056745
Full Text

Crowley, SD, Frey, CW, Gould, SK, Griffiths, R, Ruiz, P, Burchette, JL, Howell, DN, Makhanova, N, Yan, M, Kim, H-S, Tharaux, P-L, and Coffman, TM. "Simulation of lymphoctye responses by angiotensin II promotes kidney injury in hypertension (American Journal Physiology-Renal Physiology (2008) 295, (F515-F524))." American Journal of Physiology - Renal Physiology 298, no. 5 (2010): F1286-.

Full Text

Brosius, FC, Alpers, CE, Bottinger, EP, Breyer, MD, Coffman, TM, Gurley, SB, Harris, RC, Kakoki, M, Kretzler, M, Leiter, EH, Levi, M, McIndoe, RA, Sharma, K, Smithies, O, Susztak, K, Takahashi, N, Takahashi, T, and Animal Models of Diabetic Complications Consortium, . "Mouse models of diabetic nephropathy." J Am Soc Nephrol 20, no. 12 (December 2009): 2503-2512. (Review)

PMID
19729434
Full Text

Facemire, CS, Nixon, AB, Griffiths, R, Hurwitz, H, and Coffman, TM. "Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression." Hypertension 54, no. 3 (September 2009): 652-658.

PMID
19652084
Full Text

Crowley, SD, Vasievich, MP, Ruiz, P, Gould, SK, Parsons, KK, Pazmino, AK, Facemire, C, Chen, BJ, Kim, H-S, Tran, TT, Pisetsky, DS, Barisoni, L, Prieto-Carrasquero, MC, Jeansson, M, Foster, MH, and Coffman, TM. "Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis." J Clin Invest 119, no. 4 (April 2009): 943-953.

PMID
19287096
Full Text

Benigni, A, Corna, D, Zoja, C, Sonzogni, A, Latini, R, Salio, M, Conti, S, Rottoli, D, Longaretti, L, Cassis, P, Morigi, M, Coffman, TM, and Remuzzi, G. "Disruption of the Ang II type 1 receptor promotes longevity in mice." J Clin Invest 119, no. 3 (March 2009): 524-530.

PMID
19197138
Full Text

Machura, K, Steppan, D, Neubauer, B, Alenina, N, Coffman, TM, Facemire, CS, Hilgers, KF, Eckardt, K-U, Wagner, C, and Kurtz, A. "Developmental renin expression in mice with a defective renin-angiotensin system." American Journal of Physiology - Renal Physiology 297, no. 5 (2009): F1371-F1380.

PMID
19710239
Full Text

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