Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Gurley, SB, Riquier-Brison, ADM, Schnermann, J, Sparks, MA, Allen, AM, Haase, VH, Snouwaert, JN, Le, TH, McDonough, AA, Koller, BH, and Coffman, TM. "AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure." Cell Metab 13, no. 4 (April 6, 2011): 469-475.

PMID
21459331
Full Text

Sparks, MA, Parsons, KK, Stegbauer, J, Gurley, SB, Vivekanandan-Giri, A, Fortner, CN, Snouwaert, J, Raasch, EW, Griffiths, RC, Haystead, TAJ, Le, TH, Pennathur, S, Koller, B, and Coffman, TM. "Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension." Hypertension 57, no. 3 (March 2011): 577-585.

PMID
21242463
Full Text

DiLillo, DJ, Griffiths, R, Seshan, SV, Magro, CM, Ruiz, P, Coffman, TM, and Tedder, TF. "B lymphocytes differentially influence acute and chronic allograft rejection in mice." Journal of Immunology (Baltimore, Md. : 1950) 186, no. 4 (February 2011): 2643-2654.

PMID
21248259
Full Text

Stegbauer, J, and Coffman, TM. "New insights into angiotensin receptor actions: from blood pressure to aging." Current Opinion in Nephrology and Hypertension 20, no. 1 (January 2011): 84-88. (Review)

PMID
21076298
Full Text

Verlander, JW, Hong, S, Pech, V, Bailey, JL, Agazatian, D, Matthews, SW, Coffman, TM, Le, T, Inagami, T, Whitehill, FM, David, IW, Farley, DB, Kim, YH, and Wall, SM. "Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin." American Journal of Physiology - Renal Physiology 301, no. 6 (2011): F1314-F1325.

PMID
21921024
Full Text

Snoeijs, MGJ, Hoogland, PR, Boonen, B, Coffman, TM, Peutz-Kootstra, CJ, Buurman, WA, and Heurn, LWEV. "Thromboxane receptor signalling in renal ischemia reperfusion injury." Free Radical Research 45, no. 6 (2011): 699-706.

PMID
21449636
Full Text

Coffman, TM. "Under pressure: the search for the essential mechanisms of hypertension." Nature Medicine 17, no. 11 (January 2011): 1402-1409. (Review)

PMID
22064430
Full Text

Gurley, SB, Griffiths, RC, Mendelsohn, ME, Karas, RH, and Coffman, TM. "Renal actions of RGS2 control blood pressure." Journal of the American Society of Nephrology : Jasn 21, no. 11 (November 2010): 1847-1851.

PMID
20847141
Full Text

Makhanova, NA, Crowley, SD, Griffiths, RC, and Coffman, TM. "Gene expression profiles linked to AT1 angiotensin receptors in the kidney." Physiological Genomics 42A, no. 3 (November 2010): 211-218.

PMID
20807774
Full Text

Gurley, SB, and Coffman, TM. "An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy." Cell Metab 12, no. 4 (October 6, 2010): 311-312.

PMID
20889121
Full Text

Pages