Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Kraus, V. B., T. V. Stabler, G. Luta, J. B. Renner, A. D. Dragomir, and J. M. Jordan. “Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis..” Osteoarthritis Cartilage 15, no. 8 (August 2007): 966–71. https://doi.org/10.1016/j.joca.2007.02.014.

PMID
17395501
Full Text

Huebner, J. L., D. R. Seifer, and V. B. Kraus. “Erratum to "A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis" [Osteoarthritis Cartilage 15 (2007) 354-356] (DOI:10.1016/j.joca.2006.10.014).” Osteoarthritis and Cartilage 15, no. 7 (July 1, 2007). https://doi.org/10.1016/j.joca.2007.04.009.

Full Text

Allen, K. D., R. F. DeVellis, J. B. Renner, V. B. Kraus, and J. M. Jordan. “Validity and factor structure of the AUSCAN Osteoarthritis Hand Index in a community-based sample..” Osteoarthritis Cartilage 15, no. 7 (July 2007): 830–36. https://doi.org/10.1016/j.joca.2007.01.012.

PMID
17331744
Full Text

Huebner, J. L., D. R. Seifer, and V. B. Kraus. “A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis..” Osteoarthritis Cartilage 15, no. 3 (March 2007): 354–56. https://doi.org/10.1016/j.joca.2006.10.014.

PMID
17208467
Full Text

Keeling, Stephanie O., Robert Landewe, Desiree van der Heijde, Joan Bathon, Maarten Boers, Patrick Garnero, Piet Geusens, et al. “Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoid arthritis clinical trials: the example of C-reactive protein..” J Rheumatol 34, no. 3 (March 2007): 623–33.

PMID
17343310
Scholars@Duke

Huffman, K. M., J. R. Bowers, Z. Dailiana, J. L. Huebner, J. R. Urbaniak, and V. B. Kraus. “Synovial fluid metabolites in osteonecrosis..” Rheumatology (Oxford) 46, no. 3 (March 2007): 523–28. https://doi.org/10.1093/rheumatology/kel302.

PMID
17003168
Full Text

Maksymowych, Walter P., Robert Landewe, Maarten Boers, Patrick Garnero, Piet Geusens, Hani El-Gabalawy, Dick Heinegard, et al. “Development of draft validation criteria for a soluble biomarker to be regarded as a valid biomarker reflecting structural damage endpoints in rheumatoid arthritis and spondyloarthritis clinical trials..” J Rheumatol 34, no. 3 (March 2007): 634–40.

PMID
17343311
Scholars@Duke

Birmingham, James D., Vladimir Vilim, and Virginia B. Kraus. “Collagen biomarkers for arthritis applications..” Biomark Insights 1 (February 7, 2007): 61–76.

PMID
19690637
Scholars@Duke

Kraus, Virginia B., and Joanne M. Jordan. “Serum C-Reactive Protein (CRP), Target for Therapy or Trouble?.” Biomark Insights 1 (February 7, 2007): 77–80.

PMID
19690638
Scholars@Duke

Pages