Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Huebner, J. L., M. A. Hanes, B. Beekman, J. M. TeKoppele, and V. B. Kraus. “A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis..” Osteoarthritis Cartilage 10, no. 10 (October 2002): 758–67.

PMID
12359161
Scholars@Duke

Jordan, J. M., G. Luta, T. Stabler, J. B. Renner, A. D. Dragomir, M. C. Hochberg, C. G. Helmick, and V. B. Kraus. “Serum hyaluronic acid levels and radiographic knee Osteoarthritis in African-Americans and caucasians..” In Arthritis and Rheumatism, 46:S464–S464. WILEY, 2002.

Scholars@Duke

Flahiff, Charlene M., Daria A. Narmoneva, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Lori A. Setton. “Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage..” J Biomech 35, no. 9 (September 2002): 1285–90.

PMID
12163318
Scholars@Duke

Dragomir, A. D., V. B. Kraus, J. B. Renner, G. Luta, A. Clark, V. Vilim, M. C. Hochberg, C. G. Helmick, and J. M. Jordan. “Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology..” Osteoarthritis Cartilage 10, no. 9 (September 2002): 687–91.

PMID
12202121
Scholars@Duke

Vilím, V., M. Olejárová, S. Machácek, J. Gatterová, V. B. Kraus, and K. Pavelka. “Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis..” Osteoarthritis Cartilage 10, no. 9 (September 2002): 707–13.

PMID
12202123
Scholars@Duke

Dragomir, A. D., V. B. Kraus, T. Stabler, G. Luta, J. B. Renner, L. Arab, M. C. Hochberg, C. G. Helmick, and J. M. Jordan. “Lower levels of serum cartilage oligomeric matrix protein (COMP) in postmenopausal African-American and caucasian women on current hormone replacement therapy (HRT)..” In Arthritis and Rheumatism, 46:S373–S373. WILEY, 2002.

Scholars@Duke

Jordan, J. M., G. Luta, T. Stabler, J. B. Renner, A. D. Dragomir, M. C. Hochberg, C. G. Helmick, and V. B. Kraus. “Serum c-reactive protein (CRP) and osteoarthritis (OA)..” In Arthritis and Rheumatism, 46:S373–S373. WILEY, 2002.

Scholars@Duke

Fink, C., H. J. Cooper, J. L. Huebner, F. Guilak, and V. B. Kraus. “Precision and accuracy of a transportable dual-energy X-ray absorptiometry unit for bone mineral measurements in guinea pigs..” Calcif Tissue Int 70, no. 3 (March 2002): 164–69. https://doi.org/10.1007/s00223-001-1063-5.

PMID
11907713
Full Text

Clark, Amy G., Amy L. Rohrbaugh, Ivan Otterness, and Virginia B. Kraus. “The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants..” Matrix Biol 21, no. 2 (March 2002): 175–84.

PMID
11852233
Scholars@Duke

Kraus, Virginia B., Janet L. Huebner, Christian Fink, Jeffrey B. King, Spencer Brown, T Parker Vail, and Farshid Guilak. “Urea as a passive transport marker for arthritis biomarker studies..” Arthritis Rheum 46, no. 2 (February 2002): 420–27. https://doi.org/10.1002/art.10124.

PMID
11840444
Full Text

Pages