Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Hsueh, M. -. F., P. Onnerfjord, M. P. Bolognesi, M. E. Easley, and V. B. Kraus. “DIFFERENTIAL CARTILAGE TURNOVER ALONG THE HUMAN LOWER LIMB REVEALED BY PROTEIN DEAMIDATION.” In Osteoarthritis and Cartilage, 26:S32–S32. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Hsueh, M. -. F., Y. Lu, S. S. Wellman, M. P. Bolognesi, and V. B. Kraus. “FUNCTIONAL FOLATE RECEPTOR CELL-ASSOCIATED INFLAMMATORY CYTOKINES PREDICT THE PROGRESSION OF KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 26:S121–22. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Chen, Y. -. H., C. -. H. Chou, A. Khodabukus, N. Bursac, G. Truskey, W. Kraus, and V. B. Kraus. “EFFECTS OF SIMULATED MUSCLE EXERCISE ON CHONDROCYTE GENE EXPRESSION IN A 3D-ALGINATE BEAD MODEL SYSTEM.” In Osteoarthritis and Cartilage, 26:S139–40. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Spitzer, A., J. Richmond, A. Gomoll, D. G. Jones, V. B. Kraus, J. Lufkin, J. R. Johnson, and S. Kelley. “ASSESSMENT OF THE SAFETY OF REPEAT ADMINISTRATION OF TRIAMCINOLONE ACETONIDE EXTENDED-RELEASE INJECTABLE SUSPENSION IN PATIENTS WITH KNEE OSTEOARTHRITIS: TRIAL DESIGN, METHODS AND PRELIMINARY DATA.” In Osteoarthritis and Cartilage, 26:S251–52. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Katz, N. P., P. G. Conaghan, V. B. Kraus, J. Lufkin, J. R. Johnson, and S. Kelley. “TRIAMCINOLONE ACETONIDE EXTENDED-RELEASE INJECTABLE SUSPENSION (TA-ER) PROVIDES CLINICALLY RELEVANT IMPROVEMENTS IN PAIN AND FUNCTION OF KNEE OSTEOARTHRITIS: A POOLED ANALYSIS OF 3 RANDOMIZED CLINICAL TRIALS EMPLOYING COMPOSITE ASSESSMENTS.” In Osteoarthritis and Cartilage, 26:S232–33. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Hunt, E. R., C. Jacobs, J. L. Huebner, V. B. Kraus, and C. Lattermann. “ARE SERUM CARTILAGE DEGENERATION BIOMARKER CONCENTRATIONS ACCURATE REPRESENTATIONS OF THE INTRA-ARTICULAR ENVIRONMENT OF THE KNEE?.” In Osteoarthritis and Cartilage, 26:S197–98. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Karsdal, M. A., A. -. C. Bay-Jensen, A. R. Bihlet, V. B. Kraus, I. Byrjalsen, and J. R. Andersen. “OSTEOARTHRITIS CLINICAL TRIAL DESIGN AND FOOD AND DRUG ADMINISTRATION ACCELERATED APPROVAL: LESSONS LEARNED FROM THE OSTEOPOROSIS AND LIVER FIBROSIS FIELDS.” In Osteoarthritis and Cartilage, 26:S271–S271. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Huebner, J. L., C. Haraden, Y. -. J. Li, and V. B. Kraus. “BIOMARKERS OF MACROPHAGE-ASSOCIATED INFLAMMATORY PATHWAYS ARE ASSOCIATED WITH OA SYMPTOMS AND RADIOGRAPHIC DISEASE.” In Osteoarthritis and Cartilage, 26:S42–S42. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Goode, A., V. B. Kraus, Y. Golightly, J. Huebner, S. George, J. Martin, L. DeFrate, and J. M. Jordan. “ASSOCIATION BETWEEN N-CADHERIN, KERATIN-19 AND LUMICAN WITH DISC SPACE NARROWING: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT.” Osteoarthritis and Cartilage 26 (April 1, 2018): S421–S421.

Scholars@Duke

Peterson, R. O., S. R. Hoy, L. M. Vucetich, J. A. Vucetich, V. B. Kraus, and J. L. Huebner. “URINARY BIOMARKERS TO NON-INVASIVELY EVALUATE HEALTH IN WILD MOOSE (ALCES ALCES).” In Osteoarthritis and Cartilage, 26:S196–97. ELSEVIER SCI LTD, 2018.

Scholars@Duke

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