Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982


Flowers, P, Cleveland, R, Schwartz, T, Nelson, A, Kraus, V, Hillstrom, H, Goode, A, Hannan, M, Renner, J, Jordan, J, and Golightly, Y. "Association of joint hypermobility and lower body osteoarthritis by race." April 2017.

Full Text

Huebner, J, Furman, B, Kimmerling, K, Olson, S, Guilak, F, and Kraus, V. "Identification of biomarkers indicative of synovitis in the mouse articular fracture model of PTA." April 2017.

Full Text

Furman, B, Kimmerling, K, Ramamoorthy, S, Li, Y-J, Wu, Y-H, Huebner, J, Guilak, F, Kraus, V, and Olson, S. "Articular fracture upregulates lipid metabolites in human synovial fluid." April 2017.

Full Text

Conaghan, P, Strand, V, Hunter, D, Kraus, V, Berenbaum, F, Katz, N, Lufkin, J, Johnson, J, Kelley, S, and Bodick, N. "An intra-articular, extended release formulation of triamcinolone (FX006) affords clinically relevant improvements in pain and function of knee osteoarthritis: post-hoc pooled analyses of 3 randomized controlled trials." April 2017.

Full Text

Hsueh, M-F, Kraus, V, and Onnerfjord, P. "Quantitative assessment of cartilage remodeling in health and disease." April 2017.

Full Text

Montell, E, Stabler, T, Vergés, J, and Kraus, V. "Chondroitin Sulphate Inhibits Monocyte Chemoattractant Protein-1 Release from 3T3L1 Adipocytes: A New Treatment Opportunity for Obesity-related Metabolic Syndromes?." April 2017.

Full Text

Haraden, C, Kraus, VB, Attarian, D, Laberge, R-M, and Chou, C-H. "Senescence Indicators are Positively Associated with Severity of Osteoarthritis." April 2017.

Full Text

Attur, M, Ma, S, Samuels, J, Krasnokutsky Samuels, S, Zhou, H, Bencardino, J, Hochberg, M, Mitchell, B, Kraus, V, Jordan, J, and Abramson, S. "Functional genetic polymorphism of IL-1rn encoding the IL-1 receptor antagonist predicts radiographic severity of symptomatic knee OA." April 2017.

Full Text

Lattermann, C, Jacobs, CA, Bunnell, MP, Jochimsen, KN, Abt, JP, Reinke, EK, Gammon, LG, Huebner, JL, Kraus, VB, and Spindler, KP. "Logistical challenges and design considerations for studies using acute anterior cruciate ligament injury as a potential model for early posttraumatic osteoarthritis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society 35, no. 3 (March 2017): 641-650.

Full Text

AbouAssi, H, Connelly, MA, Bateman, LA, Tune, KN, Huebner, JL, Kraus, VB, Winegar, DA, Otvos, JD, Kraus, WE, and Huffman, KM. "Does a lack of physical activity explain the rheumatoid arthritis lipid profile?." Lipids in Health and Disease 16, no. 1 (February 10, 2017): 39-null.

Full Text