Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982


Kraus, VB, McDaniel, G, Huebner, JL, Stabler, TV, Pieper, CF, Shipes, SW, Petry, NA, Low, PS, Shen, J, McNearney, TA, and Mitchell, P. "Direct in vivo evidence of activated macrophages in human osteoarthritis." OSTEOARTHRITIS AND CARTILAGE 24, no. 9 (September 2016): 1613-1621.

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Hunter, D, Nevitt, M, Lynch, J, Kraus, VB, Katz, JN, Collins, JE, Bowes, M, Guermazi, A, Roemer, FW, Losina, E, and FNIH OA Biomarkers Consortium, . "Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium." Annals of the rheumatic diseases 75, no. 9 (September 2016): 1607-1614.

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Leung, Y-Y, and Kraus, VB. "Impact of glomerular filtration rate in colchicine toxicity." Seminars in arthritis and rheumatism 45, no. 6 (June 2016): e25-. (Letter)

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Golightly, Y, Goode, A, Cleveland, R, Nelson, A, Hannan, M, Hillstrom, H, Kraus, V, Schwartz, T, Renner, J, and Jordan, J. "FRI0598 Relationship of Joint Hypermobility with Low Back Pain and Lumbar Spine Osteoarthritis: A Cohort Study." June 2016.

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Golightly, Y, Nelson, A, Hannan, M, Hillstrom, H, Kraus, V, Cleveland, R, Goode, A, Schwartz, T, Renner, J, and Jordan, J. "SAT0614 Joint Hypermobility and Ankle Osteoarthritis in A Community-Based Cohort." June 2016.

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Stabler, T, Montell, E, Vergés, J, and Kraus, V. "FRI0037 Chondroitin Sulphate Inhibition of NF-κB Activity: Attentuation of Hyaluronan Fragment Induced Inflammatory Response in Macrophages by Chondroitin Sulphate Is Mediated by Reduction in NF-κB Activity." June 2016.

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Kraus, V, Catterall, J, Soderblom, E, Moseley, M, and Suchindran, S. "Development of a serum biomarker panel highly predictive of a knee osteoarthritis diagnosis." April 2016.

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Grasso, M, Yesha, Y, Rishe, N, Kraus, V, and Niskar, A. "A big data approach for selection of a large osteoarthritis cohort." April 2016.

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Bartlett, DB, Connelly, MA, AbouAssi, H, Bateman, LA, Tune, KN, Huebner, JL, Kraus, VB, Winegar, DA, Otvos, JD, Kraus, WE, and Huffman, KM. "A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls." Arthritis research & therapy 18 (April 2016): 86-.

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Huebner, J, Furman, B, Manson, M, Kimmerling, K, Olson, S, Guilak, F, DeFrate, L, Zura, R, Reilly, R, and Kraus, V. "Acute inflammatory response after severe joint injury potentially involved in the development of post-traumatic arthritis." Osteoarthritis and Cartilage 24 (April 2016): S79-S80.

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