Mary Helen Foster, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address foste027@duke.edu

Research in the Foster Lab focuses on autoimmune glomerulonephritis, a major cause of acute and chronic kidney disease worldwide.

Our experiments explore the origins and regulation of the pathogenic immune  responses that underlie glomerulonephritis, and are designed to: identify tolerance mechanisms that regulate nephritogenic lymphocytes, with an emphasis on B cells and autoantibodies; determine the molecular basis of tolerance; identify defects in immune regulation and the contributions of genetic autoimmune predisposition; and identify environmental disease triggers. These experiments use novel models relevant to immune nephritis in both kidney-restricted and systemic autoimmunity (Goodpasture syndrome and systemic lupus erythematosus, respectively), that are amenable to mechanistic dissection using basic immunological, molecular biological, and proteomics approaches. An ultimate goal is to advance novel diagnostic and therapeutic approaches to improve the lives of patients.

Education and Training

  • Fellow in Nephrology, Medicine, Tufts University, 1985 - 1989
  • Medical Resident, Medicine, University of Virginia, 1982 - 1985
  • M.D., University of North Carolina at Chapel Hill, 1982

Publications

Clark, AG, Buckley, ES, and Foster, MH. "Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice." European journal of immunology 48, no. 3 (March 2018): 492-497.

PMID
29251774
Full Text

Clark, AG, Worni-Schudel, IM, Korte, FM, and Foster, MH. "A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities." Molecular Immunology 91 (November 2017): 49-56.

PMID
28886586
Full Text

Foster, MH. "Basement membranes and autoimmune diseases." Matrix Biology : Journal of the International Society for Matrix Biology 57-58 (January 2017): 149-168. (Review)

PMID
27496347
Full Text

Foster, MH. "Optimizing the translational value of animal models of glomerulonephritis: insights from recent murine prototypes." American Journal of Physiology Renal Physiology 311, no. 3 (September 2016): F487-F495. (Review)

PMID
27335377
Full Text

Foster, MH, Buckley, ES, Chen, BJ, Hwang, K-K, and Clark, AG. "Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen." Molecular immunology 76 (August 2016): 123-133.

PMID
27450516
Full Text

Worni-Schudel, IM, Clark, AG, Chien, T, Hwang, K-K, Chen, BJ, and Foster, MH. "Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models." Journal of translational medicine 13 (June 6, 2015): 185-.

PMID
26048777
Full Text

Clark, AG, Weston, ML, and Foster, MH. "Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model." Glycobiology 23, no. 7 (July 2013): 893-903.

PMID
23550149
Full Text

Clark, AG, Fan, Q, Brady, GF, Mackin, KM, Coffman, ED, Weston, ML, and Foster, MH. "Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice." Autoimmunity 46, no. 3 (May 2013): 188-204.

PMID
23157336
Full Text

Clark, AG, Mackin, KM, and Foster, MH. "Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells." Immunol Lett 141, no. 1 (December 30, 2011): 134-139.

PMID
21963654
Full Text

Crowley, SD, Vasievich, MP, Ruiz, P, Gould, SK, Parsons, KK, Pazmino, AK, Facemire, C, Chen, BJ, Kim, H-S, Tran, TT, Pisetsky, DS, Barisoni, L, Prieto-Carrasquero, MC, Jeansson, M, Foster, MH, and Coffman, TM. "Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis." The Journal of Clinical Investigation 119, no. 4 (April 2009): 943-953.

PMID
19287096
Full Text

Pages