Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Lemarié, CA, Simeone, SMC, Nikonova, A, Ebrahimian, T, Deschênes, M-E, Coffman, TM, Paradis, P, and Schiffrin, EL. "Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors." Circulation Research 105, no. 9 (2009): 852-859.

PMID
19762686
Full Text

Thu H, L, Steven D, C, Susan B, G, and Thomas M, C. "The Renin-Angiotensin System." (December 1, 2008): 343-357. (Chapter)

Full Text

Athirakul, K, Bradbury, JA, Graves, JP, DeGraff, LM, Ma, J, Zhao, Y, Couse, JF, Quigley, R, Harder, DR, Zhao, X, Imig, JD, Pedersen, TL, Newman, JW, Hammock, BD, Conley, AJ, Korach, KS, Coffman, TM, and Zeldin, DC. "Increased blood pressure in mice lacking cytochrome P450 2J5." FASEB J 22, no. 12 (December 2008): 4096-4108.

PMID
18716027
Full Text

Spurney, RF, and Coffman, TM. "Stressed-out podocytes in diabetes?." J Am Soc Nephrol 19, no. 11 (November 2008): 2035-2037.

PMID
18842987
Full Text

Crowley, SD, and Coffman, TM. "In hypertension, the kidney breaks your heart." Curr Cardiol Rep 10, no. 6 (November 2008): 470-476. (Review)

PMID
18950556
Scholars@Duke

Francois, H, Makhanova, N, Ruiz, P, Ellison, J, Mao, L, Rockman, HA, and Coffman, TM. "A role for the thromboxane receptor in L-NAME hypertension." Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096-F1102.

PMID
18684890
Full Text

Crowley, SD, Frey, CW, Gould, SK, Griffiths, R, Ruiz, P, Burchette, JL, Howell, DN, Makhanova, N, Yan, M, Kim, H-S, Tharaux, P-L, and Coffman, TM. "Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension." Am J Physiol Renal Physiol 295, no. 2 (August 2008): F515-F524.

PMID
18495795
Full Text

Coggins, KG, Coffman, TM, and Koller, BH. "The Hippocratic finger points the blame at PGE2." Nat Genet 40, no. 6 (June 2008): 691-692.

PMID
18509311
Full Text

Gurley, SB, and Coffman, TM. "Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages." Exp Physiol 93, no. 5 (May 2008): 538-542. (Review)

PMID
18376006
Full Text

Wooldridge, AA, Fortner, CN, Lontay, B, Akimoto, T, Neppl, RL, Facemire, C, Datto, MB, Kwon, A, McCook, E, Li, P, Wang, S, Thresher, RJ, Miller, SE, Perriard, J-C, Gavin, TP, Hickner, RC, Coffman, TM, Somlyo, AV, Yan, Z, and Haystead, TAJ. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle." J Biol Chem 283, no. 17 (April 25, 2008): 11850-11859.

PMID
18310078
Full Text

Pages