Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Gurley, SB, Allen, AM, Haase, VH, Snouwaert, JN, Koller, BH, Le, TH, and Coffman, TM. "AT1 angiotensin receptors in the proximal tubule of the kidney are essential for blood pressure regulation." October 2008.

Scholars@Duke

Crowley, SD, Frey, CW, Gould, SK, Griffiths, R, Ruiz, P, Burchette, JL, Howell, DN, Makhanova, N, Yan, M, Kim, H-S, Tharaux, P-L, and Coffman, TM. "Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension." American Journal of Physiology. Renal Physiology 295, no. 2 (August 2008): F515-F524.

PMID
18495795
Full Text

Gembardt, F, Heringer-Walther, S, van Esch, JHM, Sterner-Kock, A, van Veghel, R, Le, TH, Garrelds, IM, Coffman, TM, Danser, AHJ, Schultheiss, H-P, and Walther, T. "Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 22, no. 8 (August 2008): 3068-3077.

PMID
18497303
Full Text

Coggins, KG, Coffman, TM, and Koller, BH. "The Hippocratic finger points the blame at PGE2." Nature Genetics 40, no. 6 (June 2008): 691-692.

PMID
18509311
Full Text

Gurley, SB, and Coffman, TM. "Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages." Experimental Physiology 93, no. 5 (May 2008): 538-542. (Review)

PMID
18376006
Full Text

Wooldridge, AA, Fortner, CN, Lontay, B, Akimoto, T, Neppl, RL, Facemire, C, Datto, MB, Kwon, A, McCook, E, Li, P, Wang, S, Thresher, RJ, Miller, SE, Perriard, J-C, Gavin, TP, Hickner, RC, Coffman, TM, Somlyo, AV, Yan, Z, and Haystead, TAJ. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle." The Journal of Biological Chemistry 283, no. 17 (April 2008): 11850-11859.

PMID
18310078
Full Text

Coffman, TM, and Crowley, SD. "Kidney in hypertension: guyton redux." Hypertension (Dallas, Tex. : 1979) 51, no. 4 (April 2008): 811-816. (Review)

PMID
18332286
Full Text

Le, TH, and Coffman, TM. "Targeting genes in the renin-angiotensin system." Curr Opin Nephrol Hypertens 17, no. 1 (January 2008): 57-63. (Review)

PMID
18090671
Full Text

Henriques, TA, Crowley, SD, Frey, CW, and Coffman, TM. "COX-1 from bone marrow-derived cells promotes angiotensin II-dependent hypertension." 61st Annual High Blood Pressure Reseach Conference. Tucson, AZ. September 26, 2007 - September 29, 2007.: LIPPINCOTT WILLIAMS & WILKINS, October 1, 2007.

Scholars@Duke

Parsons, KK, Gurley, SB, Snouwaert, JN, Hill, C, Le, TH, and Coffman, TM. "Elimination of AT(1A) angiotensin receptors from smooth muscle does not alter blood pressure." October 2007.

Scholars@Duke

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