Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Crowley, SD, Gurley, SB, Herrera, MJ, Ruiz, P, Griffiths, R, Kumar, AP, Kim, H-S, Smithies, O, Le, TH, and Coffman, TM. "Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney." Proc Natl Acad Sci U S A 103, no. 47 (November 21, 2006): 17985-17990.

PMID
17090678
Full Text

Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284-16289.

PMID
17060617
Full Text

Coffman, TM. "A WNK in the kidney controls blood pressure." Nat Genet 38, no. 10 (October 2006): 1105-1106.

PMID
17006464
Full Text

Gurley, SB, Allred, A, Le, TH, Griffiths, R, Mao, L, Philip, N, Haystead, TA, Donoghue, M, Breitbart, RE, Acton, SL, Rockman, HA, and Coffman, TM. "Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice." J Clin Invest 116, no. 8 (August 2006): 2218-2225.

PMID
16878172
Full Text

Wysocki, J, Ye, M, Soler, MJ, Gurley, SB, Xiao, HD, Bernstein, KE, Coffman, TM, Chen, S, and Batlle, D. "ACE and ACE2 activity in diabetic mice." Diabetes 55, no. 7 (July 2006): 2132-2139.

PMID
16804085
Full Text

Elased, KM, Cunha, TS, Gurley, SB, Coffman, TM, and Morris, M. "New mass spectrometric assay for angiotensin-converting enzyme 2 activity." Hypertension 47, no. 5 (May 2006): 1010-1017.

PMID
16585421
Full Text

Le, TH, and Coffman, TM. "A new cardiac MASTer switch for the renin-angiotensin system." J Clin Invest 116, no. 4 (April 2006): 866-869.

PMID
16585956
Full Text

Gurley, SB, Clare, SE, Snow, KP, Hu, A, Meyer, TW, and Coffman, TM. "Impact of genetic background on nephropathy in diabetic mice." Am J Physiol Renal Physiol 290, no. 1 (January 2006): F214-F222.

PMID
16118394
Full Text

Chansel, D, Ciroldi, M, Vandermeersch, S, Jackson, LF, Gomez, A-M, Henrion, D, Lee, DC, Coffman, TM, Richard, S, Dussaule, J-C, and Tharaux, P-L. "Heparin binding EGF is necessary for vasospastic response to endothelin." The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, no. 11 (2006): 1936-1938.

PMID
16877529
Full Text

Chansel, D, Ciroldi, M, Vandermeersch, S, Jackson, LF, Gomez, A-M, Henrion, D, Lee, DC, Coffman, TM, Richard, S, Dussaule, J-C, and Tharaux, P-L. "Heparin binding EGF is necessary for vasospastic response to endothelin." FASEB Journal 20, no. 11 (2006): E1368-E1381.

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