Wednesday, July 14, 2021
Here are pearls and takeaways from the session:
- Procalcitonin is a peptide marker secreted by tissues reacting to an infection. As it is not secreted my immune cells, levels are not appreciably impacted by immunocompromising conditions.
- Early studies of procalcitonin focused on its ability to differentiate bacterial and non-bacterial infections. It is now better appreciated that procalcitonin is also elevated in severe viral infections and may therefore be a marker of severity of infection.
- Procalcitonin test performance is only validated in respiratory tract infections. Ordering a procalcitonin may be helpful when providers are uncertain about initiating antibiotics but should not delay antibiotic therapy, especially in sepsis.
- Trending levels of procalcitonin can be used to monitor response to therapy in patients with infection. Procalcitonin guided decisions for antibiotic cessation have been associated with a shorter duration of antibiotic use.
Duke Medicine Learning, Education, and Discussion Series (LEADS) takes place each Tuesday at 12 p.m. Learn more and see schedule of upcoming sessions.