Human Physiology

David D’Alessio, MD, Professor of Medicine and Chief of the Division of Endocrinology. Dr. D'Alessio has a primary research interest in the regulation of glucose tolerance and abnormalities that lead to type 2 diabetes. Work in his lab is directed at the interplay of circulating glucose, GI hormones and neural signals to control insulin secretion. The focus is the gut peptide GLP-1 and its role in normal physiology, type 2 diabetes and bariatric surgery. He and his colleagues do physiologic studies of insulin secretion in humans and complement these with mechanistic studies in animal models.

Thomas J. Weber, MD, Associate Professor of Medicine. Dr. Weber's work is centered on translating cellular and molecular findings into pertinent clinical and therapeutic applications in a variety of mineral and bone disorders. His past work contributed to a mechanistic understanding of X-linked hypophosphatemic rickets (XLH) and to current clinical trials of a novel and targeted therapy in XLH patients. He is also currently investigating the role of ex vivo calcium sensing by parathyroid tumor cells in predicting phenotypic manifestations in patients with primary hyperparathyroidism.