Institutes and Labs

The Duke Division of Hematologic Malignancies and Cellular Therapy conducts research and clinical activities in conjunction with the following Duke Departments, institutes, and centers.

Centers and Institutes

  • The Duke Cancer Institute, including the NCI-Funded Hematologic Malignancies & Cellular Therapy Research Program, integrates patient care, research and education to improve patient outcomes and accelerate scientific progress. 
  • Duke Center for Genomic and Computational Biology is an interdisciplinary center where faculty across Duke’s campus collaborate to study complex problems in genomic and computational biology, train researchers and develop genomic technologies.
  • Duke Clinical Research Institute independent academic research organization, is able to challenge conventional approaches and explore innovative ways to accelerate the translation of scientific discovery into better care for patients everywhere.
  • Duke Department of Immunology seeks to further knowledge and understanding of immunological principles and mechanisms by conducting outstanding and cutting-edge research in basic immunology.
  • Duke Department of Pathology comprises basic, translational and clinical researchers, as well as diagnostic pathologists.
  • Duke Department of Pharmacology & Cancer Biology addresses a myriad of important scientific questions relevant to cancer, metabolism, nervous system function, drugs of abuse, and environmental toxicants.
  • Duke Global Health Institute is committed to developing and employing new models of education and research that engage international partners and find innovative solutions to global health challenges.
  • Duke Marcus Center for Cellular Cures seeks to develop transformative clinical therapies using cells, tissues, molecules, genes, and biomaterials to treat diseases and injuries currently lacking effective treatments.
  • Duke Regeneration NEXT seeks to replace lost, damaged or diseased tissue with new, healthy tissue through procedures not requiring organ donation and transplantation.
  • Duke Dermatology Specialty Clinics are committed to providing the highest level of patient care to all patients with skin disease; especially those with severe and difficult to treat and diagnosis diseases, while adhering to the highest ethical standards in our individual and collective work.
  • Duke MedX Engineering Innovation in Medicine  fosters the exchange of ideas and creates research opportunities between physicians, engineers, computer scientists, researchers and innovators.

Labs

The Chao Lab: Research in the Chao Lab focuses on two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. 

The Chen Lab: Reseach in the Chen lab focuses on Experimental stem cell transplantation: GVHD/GVL, stem cell engraftment, induction of immune tolerance, novel applications.

The Sung Lab: Research in the Sung lab focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials.

The Racioppi Lab: Research in the Racioppi Lab focuses on Regulation of tumor microenvironment in breast cancer and hematological malignancies (MDSCs and DCs).

The Sipkins Lab: The Sipkins Lab studies the molecular characteristics of tissue microenvironments, or “niches,” that regulate the migration, survival and regeneration of cancerous cells.

The Dave Lab: Sandeep Dave’s lab focuses on the genomic characterization of hematologic malignancies through a combination of genomics, in vitro and in vivo modeling.

The McKinney Lab: The McKinney Lab focuses on Clinical research in lymphoid malignancies; Translational studies of genetic/genomic heterogeneity of lymphomas; and Understanding of resistance mechanisms to targeted therapeutics.

The Kang Lab: Research in the Kang lab focuses on areas to define the genes and molecules in the bone marrow stem cells and in the bone marrow micro-environment that regulate hematopoietic stem cell function and number and to identify molecules and pathways that can be used as biomarkers for treatment responses and as therapeutic targets for the treatment of multiple myeloma.

The Doan Lab: Research in the Doan Lab focuses of Identification of Novel Hematopoietic Growth Factors; Endothelial microvescicles; EGFR and EGFR-2 Signaling in Hematologic Malignancies; Hematopoietic Acute Radiation Syndrome; and Transgenic and mutant murine models in cancer and myelosuppression.

The Sarantopoulos Lab: Research in the Sarantopoulos lab focuses on the development of chronic graft versus host disease.

The Brander Lab: Research in the Brander Lab focuses on Clinical Research Projects for CLL and Indolent Lymphoma.

The Rein Lab: The Rein Lab focuses on Targeting β-arrestins in Myeloid Malignancies and CNS metastasis.