Biomedical Research

Duke Division of Nephrology faculty have active basic research programs focused on diabetic kidney disease, transplantation, calcium homeostasis and bone metabolism, inflammatory diseases of the kidney, and genetic mechanisms of hypertension.

To learn more about basic research within the division, explore one of our research labs:

The Coffman Lab

Research in the Coffman Lab addresses issues relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases.

 

 

The Crowley Lab

Research in the Crowley Lab explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease.

 

 

The Gbadegesin Lab

Research in the Gbadegesin lab focuses on understanding the molecular pathogenesis of childhood onset nephrotic syndrome, focal segmental glomerulosclerosis (FSGS) and vesicoureteric reflux (a common congenital malformation of the kidney and the urinary tract). The lab uses a combination of linkage analysis and whole exome sequencing coupled with functional studies to uncover novel genetic mutations linked to kidney disease.

The Foster Lab

The Foster Lab focuses on autoimmune glomerulonephritis, a major cause of acute and chronic kidney disease worldwide.

 

 

The Grabner Lab

The Grabner lab focuses on analyzing molecular mechanisms that contribute to chronic kidney disease (CKD) and the cardio-renal syndrome.

 

 

The Hall Lab

The Hall lab is focused on defining the molecular underpinnings of podocyte injury and dysfunction in nephrotic syndrome (NS) with a primary focus on focal segmental glomerulosclerosis (FSGS)

 

 

 

The Luo Lab

The Luo lab is interested in understanding the immunological underpinnings of transplant rejection.

 

 

 

The Musah Lab

The Musah Lab aims to understand how molecular and biophysical cues can function either synergistically or independently to guide organ development and function, and how these processes can be therapeutically harnessed to treat human disease.

 

The Olabisi Lab

The Olabisi Lab focuses to delineate the mechanism by which kidney disease risk variants in APOL1 accelerate the progression of kidney disease in humans.

 

 

The Souma Lab

The Souma lab studies the basic mechanisms of kidney injuries and repair.

 

 

 

The Sparks Lab

The Sparks Lab focuses on understanding the pathogenesis of end-organ damage in hypertension and CKD. The lab also is interested in understanding how blood flow to the kidney determines basal blood pressure, natriuresis, and hypertension pathogenesis. More recently, his lab is investigating the link beforeen SARS-CoV-2 and the Renin Angiotensin System.

 

The Spurney Lab

The Spurney Lab focuses on the role of G protein coupled receptors (GPCRs) in regulating cellular physiology.

 

 

The Wolf Lab

The Wolf Lab focuses on the role of FGF23 in CKD and cardiovascular disease.

 

 

 

The Yang Lab

The Yang Lab focuses on understanding the relationship between GPCRs (EP receptors) and hypertension pathogenesis.