Basic Research

The Duke Division of Hematologic Malignancies & Cellular Therapy is home to many faculty members who are primarily basic scientists and translational researchers. We have a broad research portfolio that is well supported by multiple resources, including the National Institutes of Health, foundations, and industry. To learn more about basic research within the division, explore one of our research labs:

Nelson Chao, MD, MBA

The Chao Lab: Research in the Chao Lab focuses on two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. 

Benny Chen, MD
The Chen Lab: Reseach in the Chen lab focuses on Experimental stem cell transplantation: GVHD/GVL, stem cell engraftment, induction of immune tolerance, novel applications.

Sandeep Dave, MD
The Dave Lab: Sandeep Dave’s lab focuses on the genomic characterization of hematologic malignancies through a combination of genomics, in vitro and in vivo modeling.

Phuong Doan, MD
The Doan Lab: Research in the Doan Lab focuses of Identification of Novel Hematopoietic Growth Factors; Endothelial microvescicles; EGFR and EGFR-2 Signaling in Hematologic Malignancies; Hematopoietic Acute Radiation Syndrome; and Transgenic and mutant murine models in cancer and myelosuppression.

Yubin Kang, MD
The Kang Lab: Research in the Kang lab focuses on areas to define the genes and molecules in the bone marrow stem cells and in the bone marrow micro-environment that regulate hematopoietic stem cell function and number and to identify molecules and pathways that can be used as biomarkers for treatment responses and as therapeutic targets for the treatment of multiple myeloma.

Luigi Racioppi, MD, PhD
The Racioppi Lab: Research in the Racioppi Lab focuses on Regulation of tumor microenvironment in breast cancer and hematological malignancies (MDSCs and DCs).

Lindsay Rein, MD
The Rein Lab: The Rein Lab focuses on Targeting β-arrestins in Myeloid Malignancies and CNS metastasis.

Stefanie Sarantopoulos, MD, PhD
The Sarantopoulos Lab: Research in the Sarantopoulos lab focuses on the development of chronic graft versus host disease.

Dorothy Sipkins, MD, PhD
The Sipkins Lab: The Sipkins Lab studies the molecular characteristics of tissue microenvironments, or “niches,” that regulate the migration, survival and regeneration of cancerous cells.

Anthony Sung, MD
The Sung Lab: Research in the Sung lab focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials.