Journal Club Articles and Schedule

Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension PMID: 37467498

Direct Oral Anticoagulants Versus Warfarin Across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses From COMBINE AF PMID: 37042255

Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis PMID: 37395276
Direct Journal Link: https://www.jci.org/articles/view/168950

Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2‑year results from a randomised phase 3 trial PMID: 37591292

Primary Aldosteronism in Chronic Kidney Disease: Blood Pressure Control and Kidney and Cardiovascular Outcomes After Surgical Versus Medical Management PMID: 37593884

Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia PMID: 37754204

Survival after kidney transplantation compared with ongoing dialysis for people over 70 years of age: A matched-pair analysis PMID: 37460010

Intention-to-treat Analysis of Patients Aged 70 Years and Older Awaiting Kidney Transplantation in Post-Kidney Allocation System Era PMID: 37322588

Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial  PMID: 37837651

Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial | Critical Care Medicine | JAMA | JAMA Network (JAMA. 2023;330(16):1557-1567. doi:10.1001/jama.2023.20583) 

Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis PMID: 37921461

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes PMID: 37952131

Effect of SGLT2 Inhibitors on Discontinuation of Renin–angiotensin System Blockade: A Joint Analysis of the CREDENCE and DAPA-CKD PMID: 37876229

Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait  PMID: 37533140

"A rational approach to guide cost-effective de novo donor-specific antibody surveillance with tacrolimus immunosuppression"  PMID: 37543094

Protocolized Natriuresis-Guided Decongestion Improves Diuretic Response: The Multicenter ENACT-HF Study January 2024, PMID: 38179728

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial PMID: 35390320

Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial  PMID: 34010611

Results of a randomized double-blind placebo-controlled Phase 2 study propose iptacopan as an alternative complement pathway inhibitor for IgA nephropathy  PMID: 37914086

Renin-Angiotensin-Aldosterone System Blockade after AKI with or without Recovery among US Veterans with Diabetic Kidney Disease PMID: 37545022

A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening PMID: 38477985

Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial PMID: 3742211

Clinical trial of anti-inflammatory therapy in dialysis

Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial  PMID: 36240838

The Effects of Pantoprazole on Kidney Outcomes: Post Hoc Observational Analysis from the COMPASS Trial PMID: 38602780

Monoclonal Gammopathy and Its Association with Progression to Kidney Failure and Mortality in Patients with CKD  PMID 37948069

Restriction of Intravenous Fluid in ICU Patients with Septic Shock  PMID: 35709019

Prediction of End-Stage Kidney Disease Using Estimated Glomerular Filtration Rate With and Without Race : A Prospective Cohort Study  PMID: 35007146 

Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial 
PMID: 35579642 

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation PMID: 35584156

Dietary Potassium Intake and All-Cause Mortality in Adults Treated with Hemodialysis PMID: 34853064

Effects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial PMID: 35244702

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus PMID: 36109639

Acetazolamide in Acute Decompensated
Heart Failure with Volume Overload  PMID: 36027559

Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis: A Randomized Clinical Trial  PMID: 35353167

The Impact of Chronic Kidney Disease Stages 3–5 on Pregnancy  PMID: 33313680

Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease   PMID: 36326117

Microvascular Lung Injury and Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus-Associated Alveolar Hemorrhage and Pulmonary Vasculitis 
PMID: 36255715

Platelet-to-lymphocyte ratio and the first occurrence of peritonitis in peritoneal dialysis patients  PMID: 36585653

Removal of Small, Asymptomatic Kidney Stones and Incidence of Relapse PMID: 35947709

Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial PMID: 36152639

Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest PMID: 36720132

Kidney glycolysis serves as a mammalian phosphate sensor  
PMID 36821389

Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants PMID: 36920755

IL-11 is a crucial determinant of cardiovascular fibrosis PMID: 29160304

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome PMID: 35140116 

Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
PMID: 36270561

Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial  PMID: 37015244

Rescheduled for May 18

Integrin CD11b Contributes to Hypertension and Vascular Dysfunction Through Mediating Macrophage Adhesion and Migration PMID: 36377602

Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence PMID: 36856614

Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1  PMID 33789010

Efficacy and safety of lumasiran for infants and young children with primary hyperoxaluria type 1: 12-month analysis of the phase 3 ILLUMINATE-B trial  PMID 35913563

Lumasiran for Advanced Primary Hyperoxaluria Type 1: Phase 3 ILLUMINATE-C Trial PMID 35843439

Pre-eclampsia after Kidney Transplantation: Rates and Association with Graft Survival and Function. PMID: 37099453

“Utility of the Kidney Failure Risk Equation and Estimated GFR for Estimating Time to Kidney Failure in Advanced CKD” PMID 37301501

Digital spatial profiling of collapsing glomerulopathy PMID: 35227689

Strasma

Gaudry et al. Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial. Lancet. 2021 Apr 3;397(10281):1293-1300.

7/22/21

Husain

No article available

Pun

Souma

Keiichi Sumida et al. Laxative Use and Risk of Dyskalemia in Patients with Advanced CKD Transitioning to Dialysis. JASN April 2021, 32 (4) 950-959

Rudman-Melnick et al. Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk. JASN December 2020, 31 (12) 2793-2814

8/12/21

Cameron

Chertow et al. Vadadustat in Patients with Anemia and Non–Dialysis-Dependent CKD. N Engl J Med. 2021 Apr 29;384(17):1589-1600.

8/19/21

Savedchuk

The Overview of Tolvaptan Trials for ADPKD.

8/26/21

Grand

Ogata et al. Effect of Treating Hyperphosphatemia With Lanthanum Carbonate vs Calcium Carbonate on Cardiovascular Events in Patients With Chronic Kidney Disease Undergoing Hemodialysis: The LANDMARK Randomized Clinical Trial. JAMA. 2021 May 18;325(19):1946-1954.

9/2/21

Pun

Research in Progress

9/9/21

Murray

Foster

Pyfrom et al. The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2024624118.

9/16/21

Roberts

Anker et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Aug 27. Online ahead of print.

Packer et al. Empagliflozin and Major Renal Outcomes in Heart Failure. N Engl J Med. 2021 Aug 27. Online ahead of print.

9/23/21

Geherty

Sanoff

Pitt et al. Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes. N Engl J Med. 2021 Aug 28. Online ahead of print.

Reese et al. Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the United States: A Comparison of International Transplant Practices and
Outcomes. J Am Soc Nephrol. 2021 Feb;32(2):397-409.

9/30/21

Smith

Sparks

Cooper et al. Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis. 
N Engl J Med. 2014 Jan 2;370(1):13-22.

Watanabe et al. Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis. Circ Res. 2021 Jul 9;129(2):262-276.

10/14/21

Cameron

Liu et al. Accounting for Age in the Definition of Chronic Kidney Disease. JAMA Intern Med. 2021 Oct 1;181(10):1359-1366.

10/21/21

Kovalik

Sun et al. Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes. Clin J Am Soc Nephrol. 2021 Aug;16(8):1201-1209.

11/4/21

Berkoben

Sterns et al. Osmotic demyelination syndrome following correction of hyponatremia. N Engl J Med. 1986 Jun 12;314(24):1535-42. 

11/11/21

Yang

Research in Progress

11/18/21

Kourany

Jones

Agarwal et al. Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease. N Engl J Med. 2021 Nov 5.

Zampieri et al. Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. JAMA. 2021;326(9):818–829.

12/2/21

Middleton

Lehrich

Heerspink et al. A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function. Kidney Int. 2021 Sep 22;S0085-2538(21)00865-6.

Sibbel et al. Real-World Effectiveness and Immunogenicity of BNT162b2 and mRNA-1273 SARS-CoV2 Vaccines in Patients on Hemodialysis. J Am Soc Nephrol. 2021 Nov 17;ASN.2021060778.

12/9/21

R. Hall

Kimura et al. Association of Polypharmacy with Kidney Disease Progression in Adults with CKD. Clin J Am Soc Nephrol. 2021 Nov 15;CJN.03940321.

12/16/21

Diamantidis

Crowley

Killian et al. Evaluation of Community-Level Vulnerability and Racial Disparities
in Living Donor Kidney Transplant. JAMA Surg. 2021 Dec 1;156(12):1120-1129.

Thomas et al. IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced
Hypertension in Mice. Hypertension. 2021 Nov;78(5):1296-1309.

12/30/21

CANCELLED

1/13/22

Nystrom

Katz-Greenberg

Watts AJB, et al. Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol. 2022 Jan;33(1):238-252. PMID: 34732507.

Asrani et al. Mission accomplished? Early data from the simultaneous liver-kidney transplantation allocation policy. Am J Transplant. 2021 Nov;21(11):3513-3515.

1/20/22

Opeyemi Olabisi

Research in Progress

1/27/22

Smith

Wang et al. Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion. Ann Intern Med. 2021 Dec 28. Online ahead of print.

2/3/22

Duronville

Onukwuli

Singh et al. Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis. N Engl J Med 2021; 385:2325-2335

Gerstein et al. Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes. N Engl J Med 2021; 385:896-907.

2/10/22

Ashley-Koch

Research in Progress

2/17/22

Robbins

Middleton

Fernández-Juárez G, et al STARMEN Investigators. The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy. Kidney Int. 2021 Apr;99(4):986-998. PMID: 33166580.

Johansen KL, et al. Catheter-Associated Bloodstream Infections among Patients on Hemodialysis: Progress before and during the COVID-19 Pandemic. Clin J Am Soc Nephrol. 2022 Feb 2:CJN.11360821. doi: 10.2215/CJN.11360821. Epub ahead of print. PMID: 35110377.

2/24/22

Ellis

Schub

Ibrahim H et al. Intermediate Renal Outcomes, Kidney Failure, and Mortality in Obese Kidney Donors. JASN. 2021 Nov; 32(11) 2933-2947.

Paige M. et al. First clinical-grade porcine kidney xenotransplant using a human decedent model. American Journal of Transplantation. 2022 Jan. Online ahead of print. PMID: 35049121.

3/3/22

Wang

MacIntyre et al. Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial. Circulation. 2022;145 (6):416–423. PMID: 35130054.

3/10/22

Diamantidis

Research in Progress

3/17/22

Kourany

Chow CK et al. Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial. Lancet. 2021 Sep 18;398(10305):1043-1052. PMID: 34469767

Berkoben

Sanoff

Stremke ER, Wiese GN, Moe SM, et al.  Intestinal Phosphorus Absorption in Moderate CKD and Healthy Adults Determined Using a Radioisotopic Tracer.  J Am Soc Nephrol 32: 2057-2069, 2021. PMID: 34244325

Budde et al. Conversion from Calcineurin Inhibitor– to Belatacept-Based Maintenance Immunosuppression in Renal Transplant Recipients: A Randomized Phase 3b Trial. 
J Am Soc Nephrol. 2021 Oct 27;32(12):3252-3264. PMID: 34706967

4/14/22

Butterly

Edmonston

Shaman et al. Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER. Circulation. 2022 Feb 22;145(8):575-585. PMID: 34903039

Massy et al. Association of Serum Phosphate with Efficacy of Statin
Therapy in Hemodialysis Patients. Clin J Am Soc Nephrol. 2022 Apr;17(4):546-554.
PMID: 35236715

4/21/22

Kovalik

Sinclair

Kramers et al. Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clin J Am Soc Nephrol. 2022 Apr;17(4):507-517.

Fried et al. High unmet treatment needs in patients with chronic kidney disease and type 2 diabetes: real-world evidence from a US claims database. Nephrol Dial Transplant. 2022 Apr 7

4/28/22

Spurney

Research in Progress

5/5/22

Katz-Greenberg

Musgrove

Wayda et al. Optimal patient selection for simultaneous heart-kidney
transplant: A modified cost-effectiveness
analysis. Am J Transplant. 2022 Apr;22(4):1158-1168

Provenzano et al. Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and their Combination in Patients with Chronic Kidney Disease: A Randomized Cross-over Clinical Trial.  J Am Soc Nephrol. 2022 Apr 19

5/12/22

Ortiz

Arnaud et al. Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms. J Am Soc Nephrol. 2022 Jun;33(6):1154-1171.

5/19/22

Crowley

Research In Progress

5/26/22

Foster

Research in Progress

6/2/22

Lucas

Tita et al. Treatment for Mild Chronic Hypertension during Pregnancy. N Engl J Med. 2022 May 12;386(19):1781-1792.

6/9/22

Souma

Research in Progress

6/16/22

Edmonston

Research in Progress

Research in Progress

Research in Progress