Journal Club Articles and Schedule

a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series -
  "Study Design: Pragmatic vs Explanatory Trials"

and

"Higher versus Lower Phosphate Targets for Patients Undergoing In-Center Hemodialysis: A Randomized Controlled Trial" 
PMID: 40638247

Kidney Parameters with Tirzepatide in Obesity with or without Type 2 Diabetes  
PMID: 40512543

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series
"Study Design: Repeated Measures & Modeling in Clinical Studies"

Primary Care Use and Clinical Outcomes Among Patients Initiating Hemodialysis

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series
  "Study Design: Emulating RCTs with Observational Data"

Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias 
PMID: 40879429  

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series
  "Interpreting Outcomes:
      The Models Behind Odds Ratios, Hazard Ratios, and Relative Risk"

Potassium levels after liver reperfusion in adult patients undergoing cadaveric liver transplantation: A retrospective cohort study  
PMID: 32477508  PMCID: PMC7251297

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:

  "Prediction and Discrimination:  Making Sense of Test Performance"

Predictive Value of the Oxford Classification for the Effect of Glucocorticoid Therapy in IgA Nephropathy J Am Soc Nephrol. 
2025 Jul 8. Online ahead of print. PMID: 40627446 DOI: 10.1681/ASN.0000000796

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:

      "Surviving Survival Analysis"

Prevalence of Elevated Blood Pressure and Risk Factors for Hypertension in College Athletes 
PMID: 34184859

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:

    "Collinearity in Clinical Models: When Predictors Compete"

Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain  
PMID: 39089576

Drivers and mechanisms of cognitive decline in chronic kidney disease  
PMID: 40281076

Targeting IL-16 to Protect Angiotensin II-induced Hypertension and Renal Injury  
PMID:  40955570

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:

    "Analyzing and Interpreting Correlation in Clinical Research"

A Conservative Dialysis Strategy and Kidney Function Recovery in
Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial 
PMID: 41201895

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:

    "Sample Size and Statistical Power"

A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy  
PMID: 41196369

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:

    "Interim Analyses in Clinical Trials"

Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study  
PMID: 41016405, DOI: 10.1016

  and

Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN  
PMID: 41337715, DOI: 10.1056

Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis  PMID: 41201837, DOI: 10.1056

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series

   "Recurrent Events Analysis"

A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial - PubMed
PMID: 41242333

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:  "Novel Adaptive Trial Designs in Nephrology"

Urine Electrolyte to Predict Treatment Failure of Fluid Restriction in Syndrome of Inappropriate Antidiuresis: A Prospective Multicenter Study
PMID:40711825

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:   "Internal and External Validation"

The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial 
PMID: 35228754

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series
  "Hierarchical Composite Outcomes "

Antihypertensive Drug Treatment and the Risk for Intrahemodialysis Hypotension PMID: 39012707

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series
  "Inverse Probability of Treatment Weighting in Observational Research "

IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4 PMID: 32938919

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series 

"Deriving mechanism from omics data"

Reassuring pregnancy outcomes in women with mild COL4A3-5 related disease (Alport syndrome) and genetic type of disease can aid in personalized counseling 
PMID: 38382843

Immediately following, Daniel Edmonston will present a Ten-Minute Statistical Tools to Interpret the Medical Literature series

"Repeated measures analysis and eGFR slope"

“Avacopan Data Tampering Claims”

PMID: 33596356 and FDA document Proposal to Withdraw Marketing Approval

Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial 
PMID: 41887242

Immediately following, Daniel Edmonston, will present a Ten-Minute Statistical Tools to Interpret the Medical Literature series

"Bayesian Methodology in Clinical Trials"

Sodium Correction Rates and Associated Outcomes Among Patients with Severe Hyponatremia 
PMID: 41587479

Immediately following, Daniel Edmonston will present a session of Ten-Minute Statistical Tools to Interpret the Medical Literature series:

      " Targeted maximum likelihood estimation"

Survival after kidney transplantation compared with ongoing dialysis for people over 70 years of age: A matched-pair analysis PMID: 37460010

Intention-to-treat Analysis of Patients Aged 70 Years and Older Awaiting Kidney Transplantation in Post-Kidney Allocation System Era PMID: 37322588

Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial  PMID: 37837651

Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial | Critical Care Medicine | JAMA | JAMA Network (JAMA. 2023;330(16):1557-1567. doi:10.1001/jama.2023.20583) 

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial PMID: 35390320

Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial  PMID: 34010611

IL-11 is a crucial determinant of cardiovascular fibrosis PMID: 29160304

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome PMID: 35140116 

Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia   
         

Integrin CD11b Contributes to Hypertension and Vascular Dysfunction Through Mediating Macrophage Adhesion and Migration PMID: 36377602

Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence PMID: 36856614

Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1  PMID 33789010

Efficacy and safety of lumasiran for infants and young children with primary hyperoxaluria type 1: 12-month analysis of the phase 3 ILLUMINATE-B trial  PMID 35913563

Lumasiran for Advanced Primary Hyperoxaluria Type 1: Phase 3 ILLUMINATE-C Trial PMID 35843439

Digital spatial profiling of collapsing glomerulopathy PMID: 35227689

7/15/21

7/29/21

Pun

Souma

Keiichi Sumida et al. Laxative Use and Risk of Dyskalemia in Patients with Advanced CKD Transitioning to Dialysis. JASN April 2021, 32 (4) 950-959

Rudman-Melnick et al. Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk. JASN December 2020, 31 (12) 2793-2814

Murray

Foster

Anker et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Aug 27. Online ahead of print.

Packer et al. Empagliflozin and Major Renal Outcomes in Heart Failure. N Engl J Med. 2021 Aug 27. Online ahead of print.

Geherty

Sanoff

Pitt et al. Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes. N Engl J Med. 2021 Aug 28. Online ahead of print.

Reese et al. Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the United States: A Comparison of International Transplant Practices and
Outcomes. J Am Soc Nephrol. 2021 Feb;32(2):397-409.

Smith

Sparks

Cooper et al. Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis. 
N Engl J Med. 2014 Jan 2;370(1):13-22.

Watanabe et al. Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis. Circ Res. 2021 Jul 9;129(2):262-276.

Kourany

Jones

Agarwal et al. Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease. N Engl J Med. 2021 Nov 5.

Zampieri et al. Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. JAMA. 2021;326(9):818–829.

Middleton

Lehrich

Heerspink et al. A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function. Kidney Int. 2021 Sep 22;S0085-2538(21)00865-6.

Sibbel et al. Real-World Effectiveness and Immunogenicity of BNT162b2 and mRNA-1273 SARS-CoV2 Vaccines in Patients on Hemodialysis. J Am Soc Nephrol. 2021 Nov 17;ASN.2021060778.

Diamantidis

Crowley

Killian et al. Evaluation of Community-Level Vulnerability and Racial Disparities
in Living Donor Kidney Transplant. JAMA Surg. 2021 Dec 1;156(12):1120-1129.

Thomas et al. IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced
Hypertension in Mice. Hypertension. 2021 Nov;78(5):1296-1309.

Nystrom

Katz-Greenberg

Watts AJB, et al. Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol. 2022 Jan;33(1):238-252. PMID: 34732507.

Asrani et al. Mission accomplished? Early data from the simultaneous liver-kidney transplantation allocation policy. Am J Transplant. 2021 Nov;21(11):3513-3515.

Smith

Duronville

Onukwuli

Singh et al. Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis. N Engl J Med 2021; 385:2325-2335

Gerstein et al. Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes. N Engl J Med 2021; 385:896-907.

Robbins

Middleton

Fernández-Juárez G, et al STARMEN Investigators. The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy. Kidney Int. 2021 Apr;99(4):986-998. PMID: 33166580.

Johansen KL, et al. Catheter-Associated Bloodstream Infections among Patients on Hemodialysis: Progress before and during the COVID-19 Pandemic. Clin J Am Soc Nephrol. 2022 Feb 2:CJN.11360821. doi: 10.2215/CJN.11360821. Epub ahead of print. PMID: 35110377.

Ellis

Schub

Ibrahim H et al. Intermediate Renal Outcomes, Kidney Failure, and Mortality in Obese Kidney Donors. JASN. 2021 Nov; 32(11) 2933-2947.

Paige M. et al. First clinical-grade porcine kidney xenotransplant using a human decedent model. American Journal of Transplantation. 2022 Jan. Online ahead of print. PMID: 35049121.

Berkoben

Sanoff

Stremke ER, Wiese GN, Moe SM, et al.  Intestinal Phosphorus Absorption in Moderate CKD and Healthy Adults Determined Using a Radioisotopic Tracer.  J Am Soc Nephrol 32: 2057-2069, 2021. PMID: 34244325

Budde et al. Conversion from Calcineurin Inhibitor– to Belatacept-Based Maintenance Immunosuppression in Renal Transplant Recipients: A Randomized Phase 3b Trial. 
J Am Soc Nephrol. 2021 Oct 27;32(12):3252-3264. PMID: 34706967

Butterly

Edmonston

Shaman et al. Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER. Circulation. 2022 Feb 22;145(8):575-585. PMID: 34903039

Massy et al. Association of Serum Phosphate with Efficacy of Statin
Therapy in Hemodialysis Patients. Clin J Am Soc Nephrol. 2022 Apr;17(4):546-554.
PMID: 35236715

Kovalik

Sinclair

Kramers et al. Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clin J Am Soc Nephrol. 2022 Apr;17(4):507-517.

Fried et al. High unmet treatment needs in patients with chronic kidney disease and type 2 diabetes: real-world evidence from a US claims database. Nephrol Dial Transplant. 2022 Apr 7

Katz-Greenberg

Musgrove

Wayda et al. Optimal patient selection for simultaneous heart-kidney
transplant: A modified cost-effectiveness
analysis. Am J Transplant. 2022 Apr;22(4):1158-1168

Provenzano et al. Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and their Combination in Patients with Chronic Kidney Disease: A Randomized Cross-over Clinical Trial.  J Am Soc Nephrol. 2022 Apr 19