Journal Club Articles and Schedule

Duke Nephrology Journal Club is held remote weekly on 
Thursday morning, 8:30 a.m. to 9:00 a.m. (EST).

2022-2023 Schedule

Date Speaker/Topic Article
July 21, 2022 Pao-Hwa Lin
Rice Diet Project 
Research in Progress
July 28, 2022 Rasheeda Hall Impact of Polypharmacy on Health-Related Quality of Life in Dialysis Patients - PubMed (  PMID: 34518456
August 4, 2022 John Musgrove

Restriction of Intravenous Fluid in ICU Patients with Septic Shock  PMID: 35709019

August 11, 2022 John Middleton

Prediction of End-Stage Kidney Disease Using Estimated Glomerular Filtration Rate With and Without Race : A Prospective Cohort Study  PMID: 35007146 

August 18, 2022 Blake Cameron Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF) PMID: 35766022
August 25, 2022 David Ortiz-Melo

Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial 
PMID: 35579642 

September 1, 2022 Scott Sanoff

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation PMID: 35584156

September 8, 2022 Allison Ashley-Koch Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait  PMID: 35759254
September 15, 2022 Pat Pun

Dietary Potassium Intake and All-Cause Mortality in Adults Treated with Hemodialysis PMID: 34853064

September 22, 2022 John Roberts The Efficacy and Safety of SGLT2 Inhibitor in Diabetic Kidney Transplant Recipients PMID: 35768908
September 29, 2022 Opeyemi Olabisi

Effects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial PMID: 35244702

October 6, 2022 Matt Sparks

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus PMID: 36109639

October 13, 2022 Micah Schub

Acetazolamide in Acute Decompensated
Heart Failure with Volume Overload
  PMID: 36027559

October 20, 2022 No Journal Club No Journal Club 
October 27, 2022 No Journal Club No Journal Club
November 3, 2022 No Journal Club No Journal Club
November 10, 2022 Cassidy Onukwuli

Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis: A Randomized Clinical Trial  PMID: 35353167

November 17, 2022 Brian Jones Empagliflozin in Patients with Chronic Kidney Disease
PMID: 36331190
November 24, 2022 No Journal Club No Journal Club 
December 1, 2022 Scott Robbins

The Impact of Chronic Kidney Disease Stages 3–5 on Pregnancy  PMID: 33313680

December 8, 2022 Rasha Raslan

Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease   PMID: 36326117

December 15, 2022 Daniel Edmonston Treatment Effect of the SGLT2 Inhibitor Empagliflozin on
Chronic Syndrome of Inappropriate Antidiuresis: Results
of a Randomized, Double-Blind, Placebo-Controlled,
Crossover Trial
  PMID: 36396331
December 22, 2022 No Journal Club No Journal Club
December 29, 2022 No Journal Club No Journal Club 
January 5, 2023 Mary Foster

Microvascular Lung Injury and Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus-Associated Alveolar Hemorrhage and Pulmonary Vasculitis 
PMID: 36255715

January 12, 2023 Sarah Nystrom

Platelet-to-lymphocyte ratio and the first occurrence of peritonitis in peritoneal dialysis patients  PMID: 36585653

January 19, 2023 No Journal Club No Journal Club
January 26, 2023 Shawn Wang

Removal of Small, Asymptomatic Kidney Stones and Incidence of Relapse PMID: 35947709

February 2, 2023 Benjamin Catanese

Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial PMID: 36152639

February 9, 2023 John Duronville

Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest PMID: 36720132

February 16, 2023 Timothy Hopper Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension  PMID: 36342143
February 23, 2023 No Journal Club No Journal Club
March 2, 2023 No Journal Club No Journal Club
March 9, 2023 Alex Grabner

Kidney glycolysis serves as a mammalian phosphate sensor  
PMID 36821389

March 16, 2023 Wissam Kourany Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events PMID: 36516076
March 23, 2023 No Journal Club No Journal Club
March 30, 2023 James Torain

Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants PMID: 36920755

April 6, 2023 Robert Spurney

IL-11 is a crucial determinant of cardiovascular fibrosis PMID: 29160304

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome PMID: 35140116 

April 13, 2023 No Journal Club No Journal Club
April 20, 2023 Clarissa Diamantidis Medicaid Expansion and Incidence of Kidney Failure among Nonelderly Adults  PMID: 33795426
April 27, 2023 Dave Butterly

Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
PMID: 36270561

May 4, 2023 John Middleton

Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial  PMID: 37015244

May 11, 2023 Rescheduled

Rescheduled for May 18

May 18, 2023 Mike Berkoben and
Steven Crowley
Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia   

Integrin CD11b Contributes to Hypertension and Vascular Dysfunction Through Mediating Macrophage Adhesion and Migration PMID: 36377602

May 25, 2023 Shweta Punj

Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence PMID: 36856614


June 1, 2023 Steve Smith

Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1  PMID 33789010

Efficacy and safety of lumasiran for infants and young children with primary hyperoxaluria type 1: 12-month analysis of the phase 3 ILLUMINATE-B trial  PMID 35913563

Lumasiran for Advanced Primary Hyperoxaluria Type 1: Phase 3 ILLUMINATE-C Trial PMID 35843439

June 8, 2023 Harpreet Singh  
June 15, 2023 Eugene Kovalik  
June 22, 2023 Matt Sinclair  
June 29, 2023 Gentzon Hall  


Past Journal Clubs and Articles

Date Speaker Articles



Gaudry et al. Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial. Lancet. 2021 Apr 3;397(10281):1293-1300.



No article available





Keiichi Sumida et al. Laxative Use and Risk of Dyskalemia in Patients with Advanced CKD Transitioning to Dialysis. JASN April 2021, 32 (4) 950-959

Rudman-Melnick et al. Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk. JASN December 2020, 31 (12) 2793-2814



Chertow et al. Vadadustat in Patients with Anemia and Non–Dialysis-Dependent CKD. N Engl J Med. 2021 Apr 29;384(17):1589-1600.



The Overview of Tolvaptan Trials for ADPKD.



Ogata et al. Effect of Treating Hyperphosphatemia With Lanthanum Carbonate vs Calcium Carbonate on Cardiovascular Events in Patients With Chronic Kidney Disease Undergoing Hemodialysis: The LANDMARK Randomized Clinical Trial. JAMA. 2021 May 18;325(19):1946-1954.



Research in Progress




Pyfrom et al. The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2024624118.



Anker et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Aug 27. Online ahead of print.

Packer et al. Empagliflozin and Major Renal Outcomes in Heart Failure. N Engl J Med. 2021 Aug 27. Online ahead of print.





Pitt et al. Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes. N Engl J Med. 2021 Aug 28. Online ahead of print.

Reese et al. Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the United States: A Comparison of International Transplant Practices and
Outcomes. J Am Soc Nephrol. 2021 Feb;32(2):397-409.




Cooper et al. Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis. 
N Engl J Med. 2014 Jan 2;370(1):13-22.

Watanabe et al. Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis. Circ Res. 2021 Jul 9;129(2):262-276.



Liu et al. Accounting for Age in the Definition of Chronic Kidney Disease. JAMA Intern Med. 2021 Oct 1;181(10):1359-1366.



Sun et al. Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes. Clin J Am Soc Nephrol. 2021 Aug;16(8):1201-1209.



Sterns et al. Osmotic demyelination syndrome following correction of hyponatremia. N Engl J Med. 1986 Jun 12;314(24):1535-42. 



Research in Progress





Agarwal et al. Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease. N Engl J Med. 2021 Nov 5.

Zampieri et al. Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. JAMA. 2021;326(9):818–829.





Heerspink et al. A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function. Kidney Int. 2021 Sep 22;S0085-2538(21)00865-6.

Sibbel et al. Real-World Effectiveness and Immunogenicity of BNT162b2 and mRNA-1273 SARS-CoV2 Vaccines in Patients on Hemodialysis. J Am Soc Nephrol. 2021 Nov 17;ASN.2021060778.


R. Hall

Kimura et al. Association of Polypharmacy with Kidney Disease Progression in Adults with CKD. Clin J Am Soc Nephrol. 2021 Nov 15;CJN.03940321.





Killian et al. Evaluation of Community-Level Vulnerability and Racial Disparities
in Living Donor Kidney Transplant. JAMA Surg. 2021 Dec 1;156(12):1120-1129.

Thomas et al. IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced
Hypertension in Mice. Hypertension. 2021 Nov;78(5):1296-1309.




1/6/22 CANCELLED  




Watts AJB, et al. Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol. 2022 Jan;33(1):238-252. PMID: 34732507.

Asrani et al. Mission accomplished? Early data from the simultaneous liver-kidney transplantation allocation policy. Am J Transplant. 2021 Nov;21(11):3513-3515.


Opeyemi Olabisi

Research in Progress




Wang et al. Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion. Ann Intern Med. 2021 Dec 28. Online ahead of print.




Singh et al. Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis. N Engl J Med 2021; 385:2325-2335

Gerstein et al. Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes. N Engl J Med 2021; 385:896-907.



Research in Progress




Fernández-Juárez G, et al STARMEN Investigators. The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy. Kidney Int. 2021 Apr;99(4):986-998. PMID: 33166580.

Johansen KL, et al. Catheter-Associated Bloodstream Infections among Patients on Hemodialysis: Progress before and during the COVID-19 Pandemic. Clin J Am Soc Nephrol. 2022 Feb 2:CJN.11360821. doi: 10.2215/CJN.11360821. Epub ahead of print. PMID: 35110377.




Ibrahim H et al. Intermediate Renal Outcomes, Kidney Failure, and Mortality in Obese Kidney Donors. JASN. 2021 Nov; 32(11) 2933-2947.

Paige M. et al. First clinical-grade porcine kidney xenotransplant using a human decedent model. American Journal of Transplantation. 2022 Jan. Online ahead of print. PMID: 35049121.



MacIntyre et al. Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial. Circulation. 2022;145 (6):416–423. PMID: 35130054.



Research in Progress



Chow CK et al. Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial. Lancet. 2021 Sep 18;398(10305):1043-1052. PMID: 34469767




Stremke ER, Wiese GN, Moe SM, et al.  Intestinal Phosphorus Absorption in Moderate CKD and Healthy Adults Determined Using a Radioisotopic Tracer.  J Am Soc Nephrol 32: 2057-2069, 2021. PMID: 34244325

Budde et al. Conversion from Calcineurin Inhibitor– to Belatacept-Based Maintenance Immunosuppression in Renal Transplant Recipients: A Randomized Phase 3b Trial. 
J Am Soc Nephrol. 2021 Oct 27;32(12):3252-3264. PMID: 34706967




Shaman et al. Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER. Circulation. 2022 Feb 22;145(8):575-585. PMID: 34903039

Massy et al. Association of Serum Phosphate with Efficacy of Statin
Therapy in Hemodialysis Patients. Clin J Am Soc Nephrol. 2022 Apr;17(4):546-554.
PMID: 35236715




Kramers et al. Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clin J Am Soc Nephrol. 2022 Apr;17(4):507-517.

Fried et al. High unmet treatment needs in patients with chronic kidney disease and type 2 diabetes: real-world evidence from a US claims database. Nephrol Dial Transplant. 2022 Apr 7



Research in Progress




Wayda et al. Optimal patient selection for simultaneous heart-kidney
transplant: A modified cost-effectiveness
analysis. Am J Transplant. 2022 Apr;22(4):1158-1168

Provenzano et al. Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and their Combination in Patients with Chronic Kidney Disease: A Randomized Cross-over Clinical Trial.  J Am Soc Nephrol. 2022 Apr 19



Arnaud et al. Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms. J Am Soc Nephrol. 2022 Jun;33(6):1154-1171.



Research In Progress



Research in Progress



Tita et al. Treatment for Mild Chronic Hypertension during Pregnancy. N Engl J Med. 2022 May 12;386(19):1781-1792.



Research in Progress



Research in Progress

6/23/22 Sinclair

Research in Progress

6/30/22 G. Hall

Research in Progress