Division News

4 Medicine faculty among recipients of new collaborative grant program

Four faculty members from the Department of Medicine are among the recipients of a new grant program aimed at fostering interactions between researchers in the School of Medicine and the Duke campus. Eight seed grants were awarded to project teams for "Collaborative Quantitative Approaches to Problems in the Basic and Clinical Sciences."

The teams from Medicine are:

New translational research: Blood test can tell if antibiotics are needed

A team of infectious disease and genomics faculty in the Department of Medicine has been fine-tuning a test that can determine whether a respiratory illness is caused by infection from a virus or bacteria so that antibiotics can be more precisely prescribed. The research was published in the January 20 issue of Science Translational Medicine.

John Perfect on his research: It went fungal

Dr. John Perfect estimates a million cases of cryptococcal disease per year, with 600,000 deaths, most of them in sub-Saharan Africa where AIDS causes widespread immunosuppression. People can develop respiratory symptoms, like pneumonia; if the pathogen crosses the blood-brain barrier, the infection progresses to terrible, long-lasting headaches and sometimes fever. There can even be other neurological signs; cryptococcus can actually cause dementia. The problem is, even though we understand that Cryptococcal disease occurs in the immunosuppressed, we don’t know quite how the fungus sneaks through the blood-brain barrier.

Cleaning Hospital Rooms With Chemicals, UV Rays Cuts Superbug Transmissions

A new study from Duke Medicine has found that using a combination of chemicals and UV light to clean patient rooms cut transmission of four major superbugs by a cumulative 30 percent among a specific group of patients -- those who stay overnight in a room where someone with a known positive culture or infection of a drug-resistant organism had previously been treated. 

Meningitis Model Shows Infection’s Sci-Fi-Worthy Creep Into the Brain

A study led by John Perfect, MD, chief of the Division of Infectious Diseases, is using transparent fish to watch in real time as Cryptococcal meningitis takes over the brain. The resulting images are worthy of a sci-fi movie teaser, but could be valuable in disrupting the real, crippling brain infection that kills more than 600,000 people worldwide each year.