The Duke Precision Medicine Program aims to bring proven precision medicine technologies from the basic science portfolio to the clinical settings through both research and clinical programs. Precision medicine technologies are broad-based and include specific tools such as wearables or our family history risk assessment platform, as well as predictive models that incorporate multiple modalities using state of the art scientific principles like machine learning. Housed in the Division of General Internal Medicine in the Duke Department of Medicine, our team is particularly interested in incorporating 'omic technologies, such as genomics, transcriptomics, and epigenomics, into clinical environments to enhance patient care and has broad based expertise in health services research, implementation science, and complex data. 

"Precision Medicine is the future of medicine and we are excited to be on the forefront of research, advancements, and discoveries." - Lori Orlando, Director of the Duke Precision Medicine Program

Lori Orlando

Lori Orlando, MD, MHS, MMCI
Director of the Duke Precision Medicine Program

Learn more about our work

The pace of precision medicine is rapidly accelerating and it’s potential to improve individual and population health is as well. However, precision medicine’s unique complexities make it difficult to incorporate into our existing healthcare infrastructure and processes.

Our goal is to identify and address these challenges so that patients and providers have the data, tools, and resources they need to optimize health.

Research

Our team is dedicated to advancing research in precision medicine through ongoing studies through trial networks housed at Duke University.

  • GUARDD-US: Genetic testing to understand renal disease disparities across the US through the IGNITE Pragmatic Clinical Trials Network

Health Care

Our team has developed and implemented various initiatives, programs, and tools, to bring precision medicine into the hands of providers, including both clinicians and pharmacists.

  • PHASER: Pharmacogenomics Testing for Veterans program (PHASER), brings pharmacogenomic testing to Veterans across the country receiving care at a VA. Led by Founding Director, Deepak Voora, PHASER uses this type of testing to optimize prescriptions using genetic data from patients to reduce adverse side effects and improve medication outcomes. 
  • MeTree: Developed by the Duke Precision Medicine Program, MeTree is a web-based, patient-facing risk assessment tool that collects personal health information and family health history.

Education & Training

Educating the next generation of researchers and health care providers in genomics and precision medicine is part of the fabric of our values. We are committed to providing extraordinary mentorship and educational experiences to future genomics researchers, educators, and clinicians.

News & Recognition

See what's happening at the Duke Precision Medicine Program:


open forum

Tsalik, McClain, Ginsburg, Woods publish, “Comparing the Diagnostic Accuracy of Clinician Judgement to a Novel Host Response Diagnostic for Acute Respiratory Illness”

Duke Center for Applied Genomics & Precision Medicine (CAGPM) faculty member, Ephraim Tsalik, MD, PhD, is senior author in a recent publication in Open Forum Infectious Diseases on, “Comparing the Diagnostic Accuracy of Clinician Judgement to a Novel Host Response Diagnostic for Acute Respiratory Illness.” Co-authors from CAGPM include Micah McClain, MD, PhD, Geoffrey Ginsburg, MD, PhD, and Christopher Woods, MD.
CAGPM Newest PostDocs

Get to know CAGPM's newest Postdoc Fellows!

The Duke Center for Applied Genomics & Precision Medicine welcomes our two new Post-Doctoral Training in Genomic Medicine Research trainees, Nathan Hawkey, MD, and Katherine Collins, PhD. CAGPM postdoc's are supported through T32 grant funding.
Douglas E. Williamson

VA/Duke researcher Douglas E. Williamson, PhD, on cutting-edge of identifying biomarkers to guide precision treatments for PTSD

As we honor Veterans Day today, the Duke Center for Applied Genomics & Precision Medicine (CAGPM) thanks all the current service members, the many veterans who have courageously served our country and their families who have supported these individuals. Our appreciation goes beyond Veterans Day, though, as researchers at the Durham VA Health Care System, Duke, and CAGPM, including Douglas E. Williamson, PhD, are advocates for the well-being of these individuals through their studies of genomic biomarkers that hold promise for improving support for the many service members and veterans who rely on mental health care post-deployment and beyond.
Maria Iglesias

CAGPM Spotlight: Maria Iglesias de Ussel, PharmD, PhD

Maria Iglesias de Ussel, PharmD, PhD, recently joined the Duke Center for Applied Genomics & Precision Medicine as a Senior Research Scientist! Dr. Iglesias grew up in Madrid, Spain, where she trained as a PharmD and later earned her PhD. More than 20 years ago, she came to the U.S. and continued working as a scientist, first in Virology and later in Immunology.
Thank you Geoff!

Thank You Geoff Ginsburg! Ginsburg heading to NIH in January

Geoffrey S. Ginsburg, MD, PhD, a professor of medicine in cardiology, a professor in pathology, biostatistics and bioinformatics, a professor of biomedical engineering, and a professor in Duke’s School of Nursing, will leave Duke to assume the role of Chief Medical and Scientific Officer for the National Institutes of Health (NIH) All of Us Research Program, effective January 2022. Dual announcements were made on Nov. 3 by the NIH and Duke School of Medicine.