The Duke Precision Medicine Program aims to bring proven precision medicine technologies from the basic science portfolio to the clinical settings through both research and clinical programs. Precision medicine technologies are broad-based and include specific tools such as wearables or our family history risk assessment platform, as well as predictive models that incorporate multiple modalities using state of the art scientific principles like machine learning. Housed in the Division of General Internal Medicine in the Duke Department of Medicine, our team is particularly interested in incorporating 'omic technologies, such as genomics, transcriptomics, and epigenomics, into clinical environments to enhance patient care and has broad based expertise in health services research, implementation science, and complex data. 

"Precision Medicine is the future of medicine and we are excited to be on the forefront of research, advancements, and discoveries." - Lori Orlando, Director of the Duke Precision Medicine Program

Lori Orlando

Lori Orlando, MD, MHS, MMCI
Director of the Duke Precision Medicine Program

Learn more about our work

The pace of precision medicine is rapidly accelerating and it’s potential to improve individual and population health is as well. However, precision medicine’s unique complexities make it difficult to incorporate into our existing healthcare infrastructure and processes.

Our goal is to identify and address these challenges so that patients and providers have the data, tools, and resources they need to optimize health.


Our team is dedicated to advancing research in precision medicine through ongoing studies through trial networks housed at Duke University.

  • GUARDD-US: Genetic testing to understand renal disease disparities across the US through the IGNITE Pragmatic Clinical Trials Network

Health Care

Our team has developed and implemented various initiatives, programs, and tools, to bring precision medicine into the hands of providers, including both clinicians and pharmacists.

  • PHASER: Pharmacogenomics Testing for Veterans program (PHASER), brings pharmacogenomic testing to Veterans across the country receiving care at a VA. Led by Founding Director, Deepak Voora, PHASER uses this type of testing to optimize prescriptions using genetic data from patients to reduce adverse side effects and improve medication outcomes. 
  • MeTree: Developed by the Duke Precision Medicine Program, MeTree is a web-based, patient-facing risk assessment tool that collects personal health information and family health history.

Education & Training

Educating the next generation of researchers and health care providers in genomics and precision medicine is part of the fabric of our values. We are committed to providing extraordinary mentorship and educational experiences to future genomics researchers, educators, and clinicians.

News & Recognition

See what's happening at the Duke Precision Medicine Program:

Meet the New Chief Residents

The beginning of each new academic year is exciting and unique in its own way. One of the highlights for the Department of Medicine is welcoming our new Chief Residents as they assume their roles.  This year is no exception with a talented, new team of emerging leaders that includes Ann Cameron Barr, MD, Michael Cosiano, MD, Courtney Dominguez, MD, and Nathan Hirshman, MD.  Learn more about them in our special Meet the New Chiefs Spotlight.   

Faculty Development Update: Prioritizing Faculty Support

Duke Department of Medicine Faculty:

I have spent the last three months cultivating a vision for faculty development by listening to faculty  across our department. As a member of the Faculty Development Academy (FDA) in 2011, I understand the importance of initiatives that provide support for faculty to be successful.

Duke Interprofessional Education (IPE) Clinic Seeking Clinic Preceptors

The School of Medicine is seeking clinical faculty to serve as Interprofessional Education Clinic Preceptors for the upcoming academic year. Along with other interprofessional faculty, clinic preceptors will be responsible for seeing patients with ambulatory care complaints, such as might be seen in an outpatient clinic or in urgent care.

Celebrating Juneteenth with Dr. Syed, Vice Chief for Diversity, Equity and Inclusion

Dear Department of Medicine Community: As we approach June 19, we want to take a moment to acknowledge and commemorate Juneteenth, a significant day in American history.  Juneteenth represents the emancipation of enslaved African Americans and serves as a powerful reminder of the ongoing journey towards freedom, justice, and equality.

DOM Research Quality Virtual Town Hall

This Research Quality Townhall will deconstruct the internal review process for research proposals submitted to DOM Research Administration (DOMRA) and the Office of Research Administration (ORA).

WearDuke expands to provide wearables through Koru curriculum

The WearDuke study, led by co-principal investigator, Susanne Haga, PhD, associate professor of Medicine in the division of General Internal Medicine, launched in 2019 as a campus-wide health initiative to address student well-being.

Continuing Medical Education: A Pathway to Collaboration and Inspiration

The Duke Department of Medicine (DOM) has long been at the forefront of advancing medical knowledge and fostering collaboration through its Continuing Medical Education (CME) efforts. With a focus on two pivotal programs— Medicine Grand Rounds (MGR) and the Learning Education and Discussion Series (LEADS) —the department not only ensures the maintenance of professional licenses but also cultivates an environment of shared learning, innovation, and inspiration. 

MGR: A Legacy of Innovation 

Transformational Leader Quinn Capers, MD, to Deliver June 16 Greenfield Lecture

Academic medicine transformation leader Quinn Capers, IV, MD, the Rody P. Cox Professor of Internal Medicine (Cardiology) and associate dean for faculty diversity at the University of Texas Southwest School of Medicine, will deliver the June 16 Greenfield lecture with a talk entitled “Diversifying the Physician Workforce – Why We Can’t Wait.” 

The event will be held in person only beginning at 8 a.m. in Duke North, 2002. Breakfast will be served outside of the room starting at 7:45am. 

GIM Division Update with Interim Chief Dr. William Yancy

By William Yancy, MD

Interim Chief, Division of General Internal Medicine

The Division of General Internal Medicine at Duke strives to improve adult patient, family, community, and population health through exemplary patient care, education, and research. Perhaps most importantly, we have maintained core values of excellence, integrity, kindness, and commitment to health and health equity for our patients and our communities.

Dr. Wilder Leads Three-Year Study to Improve Health Literacy in Underserved Communities

Dr. Julius Wilder will lead a three-year investigational health equity patient education study to examine how diverse populations respond to various patient-education tactics such as print, digital, and video, with the goal of identifying the most effective methods and communication infrastructures for communicating relevant and important health information to diverse communities.

Q&A Spotlight: Distinguished Professors Christopher Granger and Rana Gupta

Duke University has awarded Distinguished Professorships to 44 faculty members, six from the Department of Medicine. Over the coming weeks, join us in recognizing these Distinguished Professors through our Distinguished Professor Spotlight. This week, we feature Christopher Granger, MD, and Rana Gupta, PhD.