The Duke Precision Medicine Program aims to bring proven precision medicine technologies from the basic science portfolio to the clinical settings through both research and clinical programs. Precision medicine technologies are broad-based and include specific tools such as wearables or our family history risk assessment platform, as well as predictive models that incorporate multiple modalities using state of the art scientific principles like machine learning. Housed in the Division of General Internal Medicine in the Duke Department of Medicine, our team is particularly interested in incorporating 'omic technologies, such as genomics, transcriptomics, and epigenomics, into clinical environments to enhance patient care and has broad based expertise in health services research, implementation science, and complex data. 

"Precision Medicine is the future of medicine and we are excited to be on the forefront of research, advancements, and discoveries." - Lori Orlando, Director of the Duke Precision Medicine Program

Lori Orlando

Lori Orlando, MD, MHS, MMCI
Director of the Duke Precision Medicine Program

Learn more about our work

The pace of precision medicine is rapidly accelerating and it’s potential to improve individual and population health is as well. However, precision medicine’s unique complexities make it difficult to incorporate into our existing healthcare infrastructure and processes.

Our goal is to identify and address these challenges so that patients and providers have the data, tools, and resources they need to optimize health.


Our team is dedicated to advancing research in precision medicine through ongoing studies through trial networks housed at Duke University.

Health Care

Our team has developed and implemented various initiatives, programs, and tools, to bring precision medicine into the hands of providers, including both clinicians and pharmacists.

  • PHASER: Pharmacogenomics Testing for Veterans program (PHASER), brings pharmacogenomic testing to Veterans across the country receiving care at a VA. Led by Founding Director, Deepak Voora, PHASER uses this type of testing to optimize prescriptions using genetic data from patients to reduce adverse side effects and improve medication outcomes. 
  • MeTree: Developed by the Duke Precision Medicine Program, MeTree is a web-based, patient-facing risk assessment tool that collects personal health information and family health history.

Education & Training

Educating the next generation of researchers and health care providers in genomics and precision medicine is part of the fabric of our values. We are committed to providing extraordinary mentorship and educational experiences to future genomics researchers, educators, and clinicians.

News & Recognition

See what's happening at the Duke Precision Medicine Program:

DOM Research Quality Virtual Town Hall

This Research Quality Townhall will deconstruct the internal review process for research proposals submitted to DOM Research Administration (DOMRA) and the Office of Research Administration (ORA).

WearDuke expands to provide wearables through Koru curriculum

The WearDuke study, led by co-principal investigator, Susanne Haga, PhD, associate professor of Medicine in the division of General Internal Medicine, launched in 2019 as a campus-wide health initiative to address student well-being.

GIM Division Update with Interim Chief Dr. William Yancey

By William Yancy, MD

Interim Chief, Division of General Internal Medicine

The Division of General Internal Medicine at Duke strives to improve adult patient, family, community, and population health through exemplary patient care, education, and research. Perhaps most importantly, we have maintained core values of excellence, integrity, kindness, and commitment to health and health equity for our patients and our communities.

Dr. Wilder Leads Three-Year Study to Improve Health Literacy in Underserved Communities

Dr. Julius Wilder will lead a three-year investigational health equity patient education study to examine how diverse populations respond to various patient-education tactics such as print, digital, and video, with the goal of identifying the most effective methods and communication infrastructures for communicating relevant and important health information to diverse communities.

Q&A Spotlight: Distinguished Professors Christopher Granger and Rana Gupta

Duke University has awarded Distinguished Professorships to 44 faculty members, six from the Department of Medicine. Over the coming weeks, join us in recognizing these Distinguished Professors through our Distinguished Professor Spotlight. This week, we feature Christopher Granger, MD, and Rana Gupta, PhD.

Q&A Spotlight: Distinguished Professors Steve Patierno and Svati Shah

Duke University has awarded Distinguished Professorships to 44 faculty members, six from the Department of Medicine. Over the coming weeks, join us in recognizing these Distinguished Professors through our Distinguished Professor Spotlight.  This week, we feature Drs. Steven Patierno and Svati Shah.