The Duke Precision Medicine Program aims to bring proven precision medicine technologies from the basic science portfolio to the clinical settings through both research and clinical programs. Precision medicine technologies are broad-based and include specific tools such as wearables or our family history risk assessment platform, as well as predictive models that incorporate multiple modalities using state of the art scientific principles like machine learning. Housed in the Division of General Internal Medicine in the Duke Department of Medicine, our team is particularly interested in incorporating 'omic technologies, such as genomics, transcriptomics, and epigenomics, into clinical environments to enhance patient care and has broad based expertise in health services research, implementation science, and complex data. 

"Precision Medicine is the future of medicine and we are excited to be on the forefront of research, advancements, and discoveries." - Lori Orlando, Director of the Duke Precision Medicine Program

Lori Orlando

Lori Orlando, MD, MHS, MMCI
Director of the Duke Precision Medicine Program

Learn more about our work

The pace of precision medicine is rapidly accelerating and it’s potential to improve individual and population health is as well. However, precision medicine’s unique complexities make it difficult to incorporate into our existing healthcare infrastructure and processes.

Our goal is to identify and address these challenges so that patients and providers have the data, tools, and resources they need to optimize health.

Research

Our team is dedicated to advancing research in precision medicine through ongoing studies through trial networks housed at Duke University.

  • GUARDD-US: Genetic testing to understand renal disease disparities across the US through the IGNITE Pragmatic Clinical Trials Network

Health Care

Our team has developed and implemented various initiatives, programs, and tools, to bring precision medicine into the hands of providers, including both clinicians and pharmacists.

  • PHASER: Pharmacogenomics Testing for Veterans program (PHASER), brings pharmacogenomic testing to Veterans across the country receiving care at a VA. Led by Founding Director, Deepak Voora, PHASER uses this type of testing to optimize prescriptions using genetic data from patients to reduce adverse side effects and improve medication outcomes. 
  • MeTree: Developed by the Duke Precision Medicine Program, MeTree is a web-based, patient-facing risk assessment tool that collects personal health information and family health history.

Education & Training

Educating the next generation of researchers and health care providers in genomics and precision medicine is part of the fabric of our values. We are committed to providing extraordinary mentorship and educational experiences to future genomics researchers, educators, and clinicians.

News & Recognition

See what's happening at the Duke Precision Medicine Program:


Ryanne Wu

Ryanne Wu on her path to precision medicine

Ryanne Wu, MD, MHS, Associate Professor of Medicine and faculty for the Duke Precision Medicine Program, knew she wanted to be a physician from a very young age. Now, at Duke, Wu is an internal medicine physician and health services researcher with an emphasis on precision medicine. She studies the implementation of precision medicine interventions with the goal of improving clinical care processes and outcomes. Wu is part of projects involving MeTree, a patient-facing family health history risk assessment platform designed at Duke’s Center for Applied Genomics and Precision Medicine, as well as the Veteran Affair’s Pharmacogenomic (PGx) Testing for Veterans (PHASER) program, which is working to complete PGx testing on up to 250,000 veterans by 2024.
Summer Scholars 2022 graphic

2022 Summer Scholars Officially Kicks off

The Duke Center for Genomic and Computational Biology (GCB) and the Center for Precision Medicine has partnered once again with North Carolina Central University (NCCU) for the Summer Scholars Program in Genome Sciences and Medicine, welcoming students to Durham, North Carolina.
Lori Orlando

Orlando to present during Public Health Genetics Week

Public Health Genetics Week will take place May 23-27, 2022. The virtual event, organized by the National Coordinating Center for the Regional Genetics Network, aims to increase awareness, and celebrate the efforts of the public health genetics system.
Deepak Voora

PHASER provides cutting-edge PGx testing for Veterans

Since 2019, the Durham VA has served as the coordinating center for The Pharmacogenomics Testing for Veterans program (PHASER), an exciting new program that is bringing PGx testing to Veterans across the country.
Arthur Mosley looks back

Retiring after 15 years at Duke, Arthur Moseley looks back to see forward

Martin “Arthur” Moseley, PhD, retired from Duke after 15 years of service at the end of January of 2022. Dr. Moseley is an Associate Professor of Medicine, faculty member in the Center for Applied Genomics & Precision Medicine (CAGPM), and Director of the Proteomics and Metabolomics core facility housed in the Duke Center for Genomic and Computational Biology (GCB)
STRRIDE

T32 Post-Doc Katherine Collins is first author of a new publication on personalized lifestyle interventions

Katherine Collins, PhD, one of the current Duke Center for Applied Genomics & Precision Medicine’s post-doctoral fellows in genomic medicine research, published a paper in the Translational Journal of the American College of Sports Medicine (TJACSM) characterizing the timing and self-reported determinants of exercise intervention dropout among sedentary adults with overweight or obesity. The study also sought to explore variations in adherence among individuals who completed the 6- to 8-month structured exercise intervention.
Julia Walker and her father

CAGPM’s Black History Month Spotlight on Julia Walker

Black History Month dedicates a month to reflect, celebrate, and amplifying the many accomplishments of African Americans. As a Black employee of the Duke Center for Applied Genomics & Precision Medicine, we spoke with Julia Walker, whose dedication to Duke and the Center is unmatched.