Duke Cardiovascular Physiology Core
The Duke Cardiovascular Physiology Core’s mission is to provide investigators with a central resource for creating and characterizing mouse models of cardiovascular disease. We offer state-of-the-art and comprehensive invasive and non-invasive cardiovascular phenotyping services. Non-invasive techniques include echocardiography, myocardial strain analyses, exercise capacity assessments, ambulatory and ECG monitoring. Invasive techniques include ex-vivo cardiac studies and in vivo pressure-volume loop analyses. We have extensive expertise in models of physiologic and pathologic cardiac provocation, which can be used to assess gene function or pharmacological studies. More information: Darion Rapoza, PhD.
Duke University and Duke University School of Medicine offer state-of-the-art shared research facilities that are available for use by all Duke investigators. Core facilities are physically housed and administered by Duke research institutes and centers, including the Cardiovascular Research Center.
Darion Rapoza, PhD
Lan Mao, MD
Senior Mouse Surgeon
Mouse Colony Manager
Core Echocardiogram in Mice
New--Cellular Metabolism Analysis
The Duke School of Medicine Cardiovascular Physiology Core now features a Seahorse XFe96 Flux Analyzer by Agilent Technologies, Inc. The Seahorse Analyzer is an instrument used for studies of cellular energy metabolism. The instrument determines energy utilization in living cells in real-time, by measuring both oxygen consumption rate (OCR) and the change in pH/extracellular acidification rate (ECAR) to assess multiple cellular metabolic functions.