2024 Mandel Foundation Fellow and Seed Grant Awards
Annelise Poss, PhD, mentored by Deb Muoio, PhD |
Elucidating how healthy heart mitochondria respond to changes in fuel availability |
Mandel Fellow |
Mohammed Imran Aslam, MD |
Single Nuclei RNA Sequencing of the Right Ventricle in Hemodynamically Profiled Patients with Heart Failure |
Mandel Seed |
Sharon Gerecht, PhD |
Effect of Extracellular Matrix Stiffness on Endothelial Cell Senescence |
Mandel Seed |
Sudarshan Rajagopal, MD PhD |
Functional Specialization of Beta-Arrestin Isoforms |
Mandel Seed |
Kevin W. Southerland, MD |
The Role of Spp1+ Macrophages in Peripheral Arterial Disease |
Mandel Seed |
2023 Mandel Foundation Fellow and Seed Grant Awards
Andrew Ressler, PhD, mentored by Doug Marchuk, PhD |
Elucidating Genetic Mechanisms in CCMs |
Mandel Fellow |
Sharon Gerecht, PhD and Neil Freedman, MD |
Synthetic Arterial Grafts Engineered to Resist Atherosclerosis |
Mandel Seed |
Robert W. McGarrah, MD and Christopher Holley, MD PhD |
New Regulatory Mechanisms of RNA Modification that Mediate Protein Translation in the Heart |
Mandel Seed |
Sudarshan Rajagopal, MD PhD and Ravi Karra, MD |
Location-specific Signaling by Different GPCRs in Cardiomyocytes | Mandel Seed |
Senthil Selvaraj, MD, MS, MA and Svati Shah, MD, MHS |
Metabolomic Profiling in Patients with Heart Failure with Preserved Ejection Fraction |
Mandel Seed |
Jonathan A. Stiber, Conrad Hodgkinson, PhD, and Neil J. Freedman, MD |
Atheroprotective Mechanisms of Zmynd8 |
Mandel Seed |
2022 Mandel Foundation Scholar, Fellow and Seed Grant Awards
Ravi Karra, MD |
Correction of LMNA Cardiomyopathy by Cardioediting |
Mandel Scholar |
Pavitra Murali, PhD, mentored by Sudha Shenoy, PhD |
Trafficking of Angiotensin Receptors into autophagosomes and its impact on β-arrestin-dependent signaling |
Mandel Fellow |
Neil Freedman MD and Christopher Holley, MD PhD |
Atherogenic Mechanisms of Small Nucleolar RNAs |
Mandel Seed |
Christopher Kontos, MD |
Regulation of endothelial metabolism by the Tie1 receptor tyrosine kinase |
Mandel Seed |
Huanghe Yang, PhD |
Demystify flow-activated chloride conductance in endothelium and its role in hypertension | Mandel Seed |
2021 Mandel Foundation Scholar, Fellow and Seed Grant Awards
|
|
|
---|---|---|
Dennis Abraham, MD |
Mechanosensitive TREK-1 modulates myofibroblast driven fibrosis |
Mandel Scholar |
Qiao Zhang, PhD, mentored by George Truskey, PhD |
Clinically relevant human microphysiological system disease model to investigate the effects of cellular force disruption in Cardiovascular diseases and Hutchinson-Gilford Progeria Syndrome |
Mandel Fellow |
Gayathri Viswanathan, PhD, mentored by Sudarshan Rajagopal, MD PhD |
Chronic thromboembolic pulmonary hypertension (CTEPH) and Pulmonary arterial hypertension (PAH) |
Mandel Fellow |
Laura Wingler PhD |
A High-Throughput Discovery Platform for Deep Mutational Scanning of GPCR Kinases |
Mandel Seed |
Ravi Karra, MD and Dennis Ko, MD PhD |
Genetic Regulators of Human Cardiomyocyte Proliferation |
Mandel Seed |
Sudha Shenoy PhD, collaborating with Jonathan Campbell, PhD |
Ubiquitin-dependent signaling bias at the glucagon family receptors and its impact on pancreatic β cell function |
Mandel Seed |
2020 Mandel Foundation Scholar, Fellow and Seed Grant Awards
|
|
|
---|---|---|
Robert McGarrah III, MD |
Liver-Heart Crosstalk in Obesity and Non-Alcoholic Fatty Liver Disease |
Mandel Scholar |
Jessica Regan, MD, working with research mentor Svati Shah, MD |
Cardiovascular Consequences Following Ionizing Radiation Induced Somatic Genetic and Epigenetic Changes |
Mandel Fellow |
Neil J. Freedman, MD and Christopher Holley, MD PhD |
Atherogenic Mechanisms of Small Nucleolar RNAs |
Mandel Seed |
Ravi Karra, MD, collaborating with Christopher Kontos, MD |
Modeling the myovascular niche using human induced pluripotent stem cells |
Mandel Seed |
Sudha Shenoy PhD, collaborating with Jonathan Campbell, PhD |
The role of ubiquitination in glucagon-induced signaling bias and insulin secretion |
Mandel Seed |
2019 Mandel Foundation Scholar and Seed Grant Awards
Awardees |
Title |
Award |
---|---|---|
Christopher Holley |
RNA Modifications in Cardiovascular Disease |
Mandel Scholar |
Satya Achanta |
Exosomes prevent remodeling of ventricles and improve cardiac function in myocardial infarction (MI) in a human translational model of pigs |
Mandel Seed |
Neil Freedman |
Atherogenic Mechanisms of Small Nucleolar RNAs |
Mandel Seed |
Sudha Shenoy |
Identification of molecular mechanisms that activate β-arrestin-dependent signaling |
Mandel Seed |
Robert Lefkowitz |
Novel Approaches for the Discovery of Biased Angiotensin Receptor Agonists |
Mandel Seed |
2019 Mandel Translational Research Award
Awardee |
Title |
---|---|
Lauren Truby |
Proteomic Profiling of Heart Transplant Donors and Recipients to Determine the Role of Inflammation and Immune Activation in Primary Grant Dysfunction |
2018 Mandel Foundation Scholar, Seed Grant and Fellowship Awardees
Awardees |
Title |
Award |
---|---|---|
Sudarshan Rajagopal |
Defining a Role for Beta-Arrestin-mediated VEGF Signaling in Cardiovascular Disease |
Mandel Scholar |
Jingli Cao |
Dissecting the mechanisms of epicardium-mediated heart regeneration |
Mandel Fellow |
Ravi Karra |
Genome-editing approaches for restoring regenerative capacity to the mammalian heart |
Mandel Seed |
Alexander Grabner |
The role of FGF23 and FGFR4 in cardio-renal syndrome |
Mandel Seed |
Jonathan Stiber |
Anti-Atherogenic Mechanisms of Drebrin |
Mandel Seed |
2017 Mandel Foundation Scholar, Seed Grant and Fellowship Awardees
Awardees |
Title |
Award |
---|---|---|
Ravi Karra |
Reprogramming Regenerative Capacity to the Mammalian Heart |
Mandel Scholar |
Han Kyu Lee |
Cerebrovascular Infarction (Stroke) in an Animal Model |
Mandel Fellow |
Dennis Abraham |
Protecting Cardiac Function by Harnessing the Fibroblast Secretome |
Mandel Seed |
Neil Freedman |
Molecular Mechanisms of Arteriovenous Fistula Maturation and Failure |
Mandel Seed |
Robert McGarrah |
The Role of the Nuclear Receptor, RORα, in Myocardial Metabolism |
Mandel Seed |
2016 Mandel Foundation Seed Grant and Fellowship Awardees
Awardees |
Title |
---|---|
Ravi Karra |
Genetic Approaches to Dissect Modes of Cardiac Growth in the Mammalian Heart |
Christopher Holley |
Regulation of oxidative stress by snoRNAs in hypertensive heart disease |
Mary Hutson |
Regulation of Developmental Cardiac Hypertrophy Using Radiofrequency Controlled TRP Channels |
Nathan Rudemiller |
Mandel Fellowship |
2015 Mandel Foundation Seed Grant and Fellowship Awardees
Awardees |
Title |
---|---|
Paul Rosenberg/Elizabeth Finch |
STIM-1 dependent calcium signaling in neuronal responses to hypoxia and ischemia |
Neil Freedman/Susan Gurley |
Chronic Kidney Disease Potentiates Vein Graft Disease: Cytokine-based Mechanisms |
Deepak Voora/Rima Kaddurah-Daouk |
Pharmacometabaiomic profiling of simvastatin-induced adverse events |
Robert Lefkowitz |
Molecular Mechanisms of Biased Agonism at the Angiotensin Receptor |
Stacy Johnson |
The Role of Podocyte AT1 Receptor in Hypertensive Kidney Disease |
2014 Mandel Foundation Seed Grant and Fellowship Awardees
Awardees |
Title |
---|---|
Dennis Abraham |
TREK-1 inhibition as novel therapy for treating diastolic dysfunction |
Neil Freedman |
Chronic Kidney Disease Potentiates Vein Graft Disease: Cytokine-based Mechanisms |
Christopher Kontos |
Regulation of endothelial inflammation and atherosclerosis by Caskin2, a novel Tie1-interacting protein |
Robert Lefkowitz |
Molecular Mechanisms of Biased Agonism at the Angiotensin Receptor |
Jiandong Zhang |
Tissue-dependent Activation of Interleukin 1 Receptor Contributes to the Development of Hypertension |
2013 Mandel Foundation Seed Grant and Fellowship Awardees
Awardees |
Title |
---|---|
Jonathan Stiber/Neil Freedman/Steven Crowley |
Role of Drebrin in Vascular Smooth Muscle Remodeling |
Geoffrey Pitt |
Multilevel investigations into a human CaV1.2-dependent arrhythmogenic disorder |
Matthew Wolf |
Mechanisms underlying cardiomyocyte growth decisions: proliferation vs. hypertrophy |
Sudha Shenoy/Matthew Sparks |
Roles of the deubiquitinase USP20 in AT1R signaling: impact on vasoconstriction and hypertension |
Yen Rei Yu-Fellow |
|
2012 Mandel Foundation Seed Grant and Fellowship Awardees
Awardees |
Title |
---|---|
Ken Poss |
Cardiomyocyte-Specific Expression Profiling of Scarring Versus Regeneration |
Paul Rosenberg/Maria Mirotsou |
Functional Characterization of MicroRNA-mediated in vitro and in vivo Direct Reprogramming of Fibroblasts to Cardiomyocytes |
Jonathan Stiber/Neil Freedman/Steven Crowley |
Role of Drebrin in Vascular Smooth Muscle Remodeling |
Nenad Bursac/Howard Rockman |
Cardiomyocyte-Fibroblast Interactions in 3-D Engineered Cardiac Tissues |
2011-12 CVRC Collaborative Project Initiative Awardees
Awardees |
Title |
---|---|
Nenad Bursac/Howard Rockman |
Role of Cell Fusion in Reprogramming Human MSCs into Cells with a Functional Cardiac Phenotype |
Sudha Shenoy/Neil Freedman |
Regulation of Vascular Smooth Muscle B-arrestin2 by USP20 |
Howard Rockman/Robert Lefkowitz/Mary Hutson |
The role of B-arrestin in aortic aneurysm formation in Marfan's Syndrome |
Ken Poss/Nico Katsanis |
Epigenetic Regulation of Cardiac Regeneration |
Blanche Capel/Michael Gunn |
Genetic Regulation of Critical Limb Ischemia |
Christopher Kontos/Nicholas Katsanis |
Regulation of the spermatogonial stem cell niche by testicular macrophages |
Michelle Winn/Laura Svetkey/Uptel Patel/Christopher Newgard/Beth Hauser/Svati Shah/David Goldstein |
Determinants and predictors of progressive kidney disease in African Americans |
Matthew Hirschey/Deborah Muoio |
Comprehensive survey of nutrient-induced regulation of mitochondrial protein acetylation |
Jonathan Stiber/Neil Freedman |
Role of Drebrin in Vascular Smooth Muscle Remodeling |
Kent Nilsson/Nenad Bursac/Vann Bennett |
Optical Mapping as a Method for Understanding Ankyrin Function in the Heart |