Mandel Awards

Stephanie Kereliuk, PhD Mentored by Walter Koch, PhD

'Uncovering the Therapeutic Potential and Mechanistic Role of a Novel Micro-RNA in Heart Failure

Alem W. Kahsai, PhD 

Discovery of Intracellular Site Biased Allosteric Modulators of β-Adrenergic Receptors

Sudarshan Rajagopal, MD PhD and Joshua Snyder PhD 

Illuminating location-biased GPCR signaling with confocal microscopy

Sudha K. Shenoy, PhD with collaborators  Jonathan Campbell, PhD Duke Molecular Physiology Institute and Steven Olson, PhD Sanford Burnham Prebys Medical Discovery Institute

Novel allosteric modulators targeting the glucagon receptor

Laura M. Wingler, PhD  

Leveraging Transcriptomics to Resolve Functional Differences Among Biased Angiotensin Receptor Ligands

Annelise Poss, PhD, mentored by Deb Muoio, PhD

Elucidating how healthy heart mitochondria respond to changes in fuel availability

Mohammed Imran Aslam, MD 

Single Nuclei RNA Sequencing of the Right Ventricle in Hemodynamically Profiled Patients with Heart Failure

Sharon Gerecht, PhD

Effect of Extracellular Matrix Stiffness on Endothelial Cell Senescence

Sudarshan Rajagopal, MD PhD

Functional Specialization of Beta-Arrestin Isoforms

Kevin W. Southerland, MD

The Role of Spp1+ Macrophages in Peripheral Arterial Disease

Andrew Ressler, PhD, mentored by Doug Marchuk, PhD

Elucidating Genetic Mechanisms in CCMs

Sharon Gerecht, PhD and Neil Freedman, MD

Synthetic Arterial Grafts Engineered to Resist Atherosclerosis

Robert W. McGarrah, MD and Christopher Holley, MD PhD

New Regulatory Mechanisms of RNA Modification that Mediate Protein Translation in the Heart

Sudarshan Rajagopal, MD PhD and Ravi Karra, MD

Senthil Selvaraj, MD, MS, MA and Svati Shah, MD, MHS

Metabolomic Profiling in Patients with Heart Failure with Preserved Ejection Fraction

Jonathan A. Stiber, Conrad Hodgkinson, PhD, and Neil J. Freedman, MD

Atheroprotective Mechanisms of Zmynd8

Ravi Karra, MD

Correction of LMNA Cardiomyopathy by Cardioediting

Pavitra Murali, PhD, mentored by Sudha Shenoy, PhD

Trafficking of Angiotensin Receptors into autophagosomes and its impact on β-arrestin-dependent signaling

Mandel Fellow

Neil Freedman MD and Christopher Holley, MD PhD

Atherogenic Mechanisms of Small Nucleolar RNAs

Mandel Seed

Christopher Kontos, MD

Regulation of endothelial metabolism by the Tie1 receptor tyrosine kinase

Mandel Seed

Huanghe Yang, PhD

Dennis Abraham, MD

Mechanosensitive TREK-1 modulates myofibroblast driven fibrosis  

Mandel Scholar

Qiao Zhang, PhD, mentored by George Truskey, PhD

Clinically relevant human microphysiological system disease model to investigate the effects of cellular force disruption in Cardiovascular diseases and Hutchinson-Gilford Progeria Syndrome 

Mandel Fellow

Gayathri Viswanathan, PhD, mentored by Sudarshan Rajagopal, MD PhD

Chronic thromboembolic pulmonary hypertension (CTEPH) and Pulmonary arterial hypertension (PAH)

Mandel Fellow

Laura Wingler PhD

A High-Throughput Discovery Platform for Deep Mutational Scanning of GPCR Kinases

Mandel Seed

Ravi Karra, MD and Dennis Ko, MD PhD

Genetic Regulators of Human Cardiomyocyte Proliferation

Mandel Seed

Sudha Shenoy PhD, collaborating with Jonathan Campbell, PhD

Ubiquitin-dependent signaling bias at the glucagon family receptors and its impact on pancreatic β cell function 

Mandel Seed

Robert McGarrah III, MD

Liver-Heart Crosstalk in Obesity and Non-Alcoholic Fatty Liver Disease

Mandel Scholar

Jessica Regan, MD, working with research mentor Svati Shah, MD

Cardiovascular Consequences Following Ionizing Radiation Induced Somatic Genetic and Epigenetic Changes

Mandel Fellow

Neil J. Freedman, MD and Christopher Holley, MD PhD

Atherogenic Mechanisms of Small Nucleolar RNAs

Mandel Seed

Ravi Karra, MD, collaborating with Christopher Kontos, MD

Modeling the myovascular niche using human induced pluripotent stem cells

Mandel Seed

Sudha Shenoy PhD, collaborating with Jonathan Campbell, PhD

The role of ubiquitination in glucagon-induced signaling bias and insulin secretion

Mandel Seed

Christopher Holley

RNA Modifications in Cardiovascular Disease

Mandel Scholar

Satya Achanta

Exosomes prevent remodeling of ventricles and improve cardiac function in myocardial infarction (MI) in a human translational model of pigs

Mandel Seed

Neil Freedman

Atherogenic Mechanisms of Small Nucleolar RNAs

Mandel Seed

Sudha Shenoy

Identification of molecular mechanisms that activate β-arrestin-dependent signaling

Mandel Seed

Robert Lefkowitz

Novel Approaches for the Discovery of Biased Angiotensin Receptor Agonists

Mandel Seed

Lauren Truby

Proteomic Profiling of Heart Transplant Donors and Recipients to Determine the Role of Inflammation and Immune Activation in Primary Grant Dysfunction

Sudarshan Rajagopal

Defining a Role for Beta-Arrestin-mediated VEGF Signaling in Cardiovascular Disease

Mandel Scholar

Jingli Cao

Dissecting the mechanisms of epicardium-mediated heart regeneration

Mandel Fellow

Ravi Karra

Genome-editing approaches for restoring regenerative capacity to the mammalian heart

Mandel Seed

Alexander Grabner

The role of FGF23 and FGFR4 in cardio-renal syndrome

Mandel Seed

Jonathan Stiber

Anti-Atherogenic Mechanisms of Drebrin

Mandel Seed

Ravi Karra

Reprogramming Regenerative Capacity to the Mammalian Heart

Mandel Scholar

Han Kyu Lee

Cerebrovascular Infarction (Stroke) in an Animal Model

Mandel Fellow

Dennis Abraham

Protecting Cardiac Function by Harnessing the Fibroblast Secretome

Mandel Seed

Neil Freedman

Molecular Mechanisms of Arteriovenous Fistula Maturation and Failure

Mandel Seed

Robert McGarrah

The Role of the Nuclear Receptor, RORα, in Myocardial Metabolism

Mandel Seed

Ravi Karra

Genetic Approaches to Dissect Modes of Cardiac Growth in the Mammalian Heart

Christopher Holley

Regulation of oxidative stress by snoRNAs in hypertensive heart disease

Mary Hutson

Regulation of Developmental Cardiac Hypertrophy Using Radiofrequency Controlled TRP Channels

Nathan Rudemiller

Mandel Fellowship

Paul Rosenberg/Elizabeth Finch

STIM-1 dependent calcium signaling in neuronal responses to hypoxia and ischemia

Neil Freedman/Susan Gurley

Chronic Kidney Disease Potentiates Vein Graft Disease: Cytokine-based Mechanisms

Deepak Voora/Rima Kaddurah-Daouk

Pharmacometabaiomic profiling of simvastatin-induced adverse events

Robert Lefkowitz

Molecular Mechanisms of Biased Agonism at the Angiotensin Receptor

Stacy Johnson

The Role of Podocyte AT1 Receptor in Hypertensive Kidney Disease

Dennis Abraham

TREK-1 inhibition as novel therapy for treating diastolic dysfunction

Neil Freedman

Chronic Kidney Disease Potentiates Vein Graft Disease: Cytokine-based Mechanisms

Christopher Kontos

Regulation of endothelial inflammation and atherosclerosis by Caskin2, a novel Tie1-interacting protein

Robert Lefkowitz

Molecular Mechanisms of Biased Agonism at the Angiotensin Receptor

Jiandong Zhang

Tissue-dependent Activation of Interleukin 1 Receptor Contributes to the Development of Hypertension

Jonathan Stiber/Neil Freedman/Steven Crowley

Role of Drebrin in Vascular Smooth Muscle Remodeling

Geoffrey Pitt

Multilevel investigations into a human CaV1.2-dependent arrhythmogenic disorder

Matthew Wolf

Mechanisms underlying cardiomyocyte growth decisions: proliferation vs. hypertrophy

Sudha Shenoy/Matthew Sparks

Roles of the deubiquitinase USP20 in AT1R signaling: impact on vasoconstriction and hypertension

Yen Rei Yu-Fellow

Nenad Bursac/Howard Rockman

Role of Cell Fusion in Reprogramming Human MSCs into Cells with a Functional Cardiac Phenotype

Sudha Shenoy/Neil Freedman

Regulation of Vascular Smooth Muscle B-arrestin2 by USP20

Howard Rockman/Robert Lefkowitz/Mary Hutson

The role of B-arrestin in aortic aneurysm formation in Marfan's Syndrome

Ken Poss/Nico Katsanis

Epigenetic Regulation of Cardiac Regeneration

Blanche Capel/Michael Gunn

Genetic Regulation of Critical Limb Ischemia

Christopher Kontos/Nicholas Katsanis

Regulation of the spermatogonial stem cell niche by testicular macrophages

Michelle Winn/Laura Svetkey/Uptel Patel/Christopher Newgard/Beth Hauser/Svati Shah/David Goldstein

Determinants and predictors of progressive kidney disease in African Americans

Matthew Hirschey/Deborah Muoio

Comprehensive survey of nutrient-induced regulation of mitochondrial protein acetylation

Jonathan Stiber/Neil Freedman

Role of Drebrin in Vascular Smooth Muscle Remodeling

Kent Nilsson/Nenad Bursac/Vann Bennett

Optical Mapping as a Method for Understanding Ankyrin Function in the Heart

Ken Poss

Cardiomyocyte-Specific Expression Profiling of Scarring Versus Regeneration

Paul Rosenberg/Maria Mirotsou

Functional Characterization of MicroRNA-mediated in vitro and in vivo Direct Reprogramming of Fibroblasts to Cardiomyocytes

Jonathan Stiber/Neil Freedman/Steven Crowley

Role of Drebrin in Vascular Smooth Muscle Remodeling

Nenad Bursac/Howard Rockman

Cardiomyocyte-Fibroblast Interactions in 3-D Engineered Cardiac Tissues